NUC-3373 Chemical Properties

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 100 mg/mL (162.99 mM; Need ultrasonic)

form 

Solid

pka

7.63±0.10(Predicted)

color 

White to off-white

InChIKey

BIOWRMNRHMERIO-VPUYLDKDNA-N

SMILES

O(C1=CC=CC2C=CC=CC1=2)P(=O)(N[C@@H](C)C(=O)OCC1C=CC=CC=1)OC[C@@H]1[C@H](C[C@H](N2C=C(F)C(=O)NC2=O)O1)O |&1:14,28,29,31,r|

NUC-3373 Usage And Synthesis

Uses

Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunoresearch[1][2].

in vivo

References

[1] Fiona G. McKissock, et al. Abstract 1848: NUC-3373 induces ER stress and the release of damage associated molecular patterns in colorectal cancer cells. Cancer Res August 15 2020 (80) (16 Supplement) 1848.
[2] Essam A. Ghazaly, et al. Abstract B46: NUC-3373: A novel pyrimidine nucleotide analogue that overcomes key cancer drug resistance limiting patient survival. Mol Cancer Ther December 1 2015 (14) (12 Supplement 2) B46.