4H-Isoxazolo[5,4-d][2]benzazepine-4-acetic acid, 6-(4-chlorophenyl)-1-methyl-, (4S)- Chemical Properties

Boiling point:

593.5±50.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

pka

4.19±0.10(Predicted)

4H-Isoxazolo[5,4-d][2]benzazepine-4-acetic acid, 6-(4-chlorophenyl)-1-methyl-, (4S)- Usage And Synthesis

Uses

CPI-0610 carboxylic acid is a ligand for target protein for PROTACT. CPI-0610 carboxylic acid is a potent bromodomain and extra-terminal (BET) protein inhibitor. CPI-0610 carboxylic acid has the potential in the therapy of multiple myeloma[1].

References

[1] Albrecht BK, et al. Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials. J Med Chem. 2016 Feb 25;59(4):1330-9. DOI:10.1021/acs.jmedchem.5b01882