ATG3 antibody Usage And Synthesis

Source

Rabbit

Applications

The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Recommended starting dilution is 1:1000.

Reactivity

Human;Mouse;Rat;Monkey

Immunogen

Anti-human ATG3mAb, clone PAT15F6AT, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ATG3 protein (1-314 amino acids purified from E. coli.

Background

Autophagy Related 3 (ATG3) is a conjugating enzyme essential for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. ATG3 is localizes to the cytoplasm and is expressed in tissues with predominant levels found in kidney, placenta, liver, heart and skeletal muscle. ATG3 catalyzes a reaction which is necessary for autophagy. That reaction is the formation of the Atg8-phosphatidylethanolamine (ATG-PE) conjugate.

References

[1] Reggiori, F. and Klionsky, D.J. (2002) Eukaryot Cell 1, 11-21.
[2] Ohsumi, Y. (2001) Nat Rev Mol Cell Biol 2, 211-6.
[3] Kabeya, Y. et al. (2000) EMBO J 19, 5720-8.
[4] Kabeya, Y. et al. (2004) J Cell Sci 117, 2805-12.
[5] Tanida, I. et al. (2002) J Biol Chem 277, 13739-44.
[6] Ichimura, Y. et al. (2000) Nature 408, 488-92.
[7] Schlumpberger, M. et al. (1997) J Bacteriol 179, 1068-76.
[8] Sou, Y.S. et al. (2008) Mol Biol Cell 19, 4762-75.

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