DLST antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

α-ketoglutarate dehydrogenase complex is a rate-regulating enzyme in the Krebs Cycle. Dihydrolipoamide succinyltransferase is a key subunit in this complex. Reduction of DLST increases reactive oxygen species production, suggesting its role in oxidative stress. Research has shown that deficiency of DLST in mice is linked to increased oxidative stress in mitochondria, a process that may be involved in the pathogenesis of Alzheimer's disease.

References

[1] Ohta, S. and Ohsawa, I. (2006) J Alzheimers Dis 9, 155-66.
[2] Dumont, M. et al. (2009) Free Radic Biol Med 47, 1019-27.