MCAM Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Melanoma cell adhesion molecule is an immunoglobulin superfamily member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma. Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatory bowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure. MCAM-expressing human mesenchymal stromal cells in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells through direct contact between hMSC and HSPC. Related studies suggest that activation of the Notch signaling pathway may also, in part, play a role in HSPC maintenance. Additional research indicates that MCAM may play a role in multiple sclerosis, an autoimmune inflammatory disease that affects central nervous system neurons. Endothelial MCAM within the blood-brain barrier act as adhesion receptors that permit lymphocytes to transmigrate across the barrier and produce the inflammatory lesions that characterize the disorder.

References

[1] Shih, I.M. (1999) J Pathol 189, 4-11.
[2] Stopp, S. et al. (2013) Haematologica 98, 505-13.
[3] Wang, P. et al. (2013) Mol Cell Biol 33, 3689-99.
[4] Corselli, M. et al. (2013) Blood 121, 2891-901.
[5] Duan, H. et al. (2013) Sci Rep 3, 1687.

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