STAT6 Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Upon activation by Janus kinases, Stat6 translocates to the nucleus where it regulates cytokine-induced gene expression. Stat6 is activated via phosphorylation at Tyr641 and is required for responsiveness to IL-4 and IL-13. In addition, Stat6 is activated by IFN-α in B cells, where it forms transcriptionally active complexes with Stat2 and p48. Protein phosphatase 2A is also involved in regulation of IL-4-mediated Stat6 signaling.

References

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[4] Quelle, F.W. et al. (1995) Mol. Cell. Biol. 15, 3336-3343.
[5] Takeda, K. et al. (1996) Nature 380, 627-630.
[6] Gupta, S. et al. (1999) J. Immunol. 163, 3834-3841.
[7] Woetmann, A. et al. (2003) J. Biol. Chem. 278, 2787-2791.