Basic information Safety Supplier Related

H-TYR-D-ALA-GLY-PHE-MET-NH2

Basic information Safety Supplier Related

H-TYR-D-ALA-GLY-PHE-MET-NH2 Basic information

Product Name:
H-TYR-D-ALA-GLY-PHE-MET-NH2
Synonyms:
  • TYR-D-ALA-GLY-PHE-MET-NH2
  • TYR-D-ALA-GLY-PHE-MET-NH2 ACOH H2O
  • ala(2)-enkephalinamide-me
  • ENKEPHALINAMIDE, [D-ALA2, MET5]
  • ENKEPHALIN, MET- (D-ALA2; AMIDE)
  • [D-ALA2,MET5]-ENKEPHALINAMIDE
  • [D-ALA2,MET5]-ENKEPHALINAMIDE ACOH H2O
  • D-ALA2-MET-ENKEPHALINAMIDE
CAS:
61090-95-7
MF:
C28H38N6O6S
MW:
586.7
Mol File:
61090-95-7.mol
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H-TYR-D-ALA-GLY-PHE-MET-NH2 Chemical Properties

storage temp. 
-15°C
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H-TYR-D-ALA-GLY-PHE-MET-NH2 Usage And Synthesis

Uses

[D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties[1][2].

in vivo

[D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism in Sprague-Dawley rats[1].

Animal Model:Male Sprague-Dawley rats (250-320 g)[1]
Dosage:10, 50, 100, 150, and 200 mg/kg
Administration:Intracerebroventrical injection
Result:Decreased in bile flow that ranged from 12% to 41%.
Decreased bicarbonate secretion into bile.

References

[1] Bergasa NV, et, al. The opioid peptide analog D-Ala2-Met-enkephalinamide decreases bile flow by a central mechanism. Peptides. 1999;20(8):979-86. DOI:10.1016/s0196-9781(99)00091-1
[2] PERT CB, et, al. [D-Ala2]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic. 1976 Oct 15;194(4262):330-2.

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