TYR-D-ALA-GLY-PHE-MET CAS#: 61370-87-4

TYR-D-ALA-GLY-PHE-MET Basic information

Product Name:

TYR-D-ALA-GLY-PHE-MET

Synonyms:

a,a-D-Trehaloseanhydrous
enkephalin-Met, Ala(2)-
L-TYR-D-ALA-GLY-PHE-MET
L-TYR-D-ALA-GLY-PHE-MET-OL CH3COOH
H-TYR-D-ALA-GLY-PHE-MET-OH
ENKEPHALIN, MET- (D-ALA2)
(D-ALA2) MET-ENKEPHALIN
(D-ALA2-OL)-MET ENKEPHALIN

CAS:

61370-87-4

MF:

C28H37N5O7S

MW:

587.69

Mol File:

61370-87-4.mol

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TYR-D-ALA-GLY-PHE-MET Usage And Synthesis

Description

Enkephalin-met, ala(2)- is a synthetic analog of methionine enkephalin.

Uses

[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].

in vivo

[D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice^[1].

Animal Model:	Lactating rats^[1]
Dosage:	0.01, 0.1 and 1 μg
Administration:	Intracerebroventrical injection
Result:	Inhibited ACh-induced and suckling-induced OT release.

References

[1] Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8.
[2] Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51.

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