TERT-BUTYLCARBAMIDINE HYDROCHLORIDE Chemical Properties

Melting point:

190 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

powder to crystal

color 

White to Almost white

Sensitive 

Hygroscopic

BRN 

3618865

InChIKey

ARDGQYVTLGUJII-UHFFFAOYSA-N

CAS DataBase Reference

18202-73-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

HazardClass 

IRRITANT

HS Code 

2921199990

MSDS

• Language:English Provider:ALFA

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE Usage And Synthesis

Uses

Pivalimidamide Hydrochloride is used as a reagent in the preparation of 2-alkyl-4-aryltetrahydropyridopyrimidines and 2-alkyl-4-aryl-tetrahydropyrimidoazepines as selective 5-HT2A antagonists.

Synthesis

Step (1) Preparation of tert-butylamidine hydrochloride: To a magnetically stirred mixed solution of 2,2-dimethyl-1-propanenitrile (25.0 g, 0.30 mol) and anhydrous methanol (26.8 mL, 0.79 mol) was added dropwise acetyl chloride (25 mL, 0.36 mol) and ether (30 mL) at 0 °C. After the dropwise addition, stirring was continued at 0 °C for 15 min. Subsequently, the reaction mixture was stirred at room temperature for 3 days. After completion of the reaction, white crystals were obtained by filtration, washed with ether and dried under vacuum. The dried crystals were mixed with an ethanol solution of 10% ammonia (150 mL, 0.90 mol) and stirred at room temperature for 3 days. The reaction mixture was filtered and the filtrate was concentrated to give a white solid. Recrystallization by ethanol gave a white crystalline product (18.9 g, 46% yield) with a melting point of 205°C (literature value 188°-190°C). NMR hydrogen spectrum (DMSO-d6): δ 1.22 (s, 9H), 8.63 (br d, 3H).

References

[1] Patent: US4786640, 1988, A

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE(18202-73-8)Related Product Information

• Dimethylamine
• 2,2-DIMETHYLPROPIONAMIDINE
• 1-Methyl-cyclopropanecarboxamidine HCl
• 1-(2,4-dichlorophenyl)cyclopropanecarboxamidine
• PIVALIMIDOHYDRAZIDE HYDROCHLORIDE
• ADAMANTANE-1-CARBOXAMIDINE HYDROCHLORIDE
• 5,5-Diethyl-4-(2-chlorophenyl)iminobarbituric acid
• N,N-DIMETHYL-[1-T-BUTYL-3,3-BIS(DIMETHYLAMINO)-2-AZA-3-PROPENYLIDEN]-AMMONIUM PERCHLORATE
• PYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONE, 6-CHLORO-2-(1,1-DIMETHYLETHYL)-
• 1-(4-chlorophenyl)cyclopropanecarboxamidine
• TERT-BUTYLCARBAMIDINE HYDROCHLORIDE