LORAZEPAM-D4
LORAZEPAM-D4 Basic information
- Product Name:
- LORAZEPAM-D4
- Synonyms:
-
- LORAZEPAM-D4
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(6-chlorophenyl-2,3,4,5-d4)-1,3-dihydro-3-hydroxy-
- LORAZEPAM-D4,100/MLINACETONITRILE
- Lorazepam-d4 solution
- 7-chloro-5-(2-chloro-3,4,5,6-tetradeuteriophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
- LORAZEPAM (D4, 98%) 1.0 MG/ML IN ACETONITRILE
- LORAZEPAM (D4, 98%) 100 UG/ML IN ACETONITRILE
- Lorazepam-d4 (CRM)
- CAS:
- 84344-15-0
- MF:
- C15H10Cl2N2O2
- MW:
- 321.16
- EINECS:
- 200-835-2
- Mol File:
- 84344-15-0.mol
LORAZEPAM-D4 Chemical Properties
- Flash point:
- 2℃
- storage temp.
- -20°C
- solubility
- DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
Safety Information
- Hazard Codes
- F,Xn
- Risk Statements
- 11-20/21/22-36
- Safety Statements
- 16-36/37
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 2
LORAZEPAM-D4 Usage And Synthesis
Uses
Lorazepam-d4 is labelled Lorazepam (L469850) which is a high-potency, intermediate-duration, 3-hydroxy benzodiazepine drug, It is often used to treat anxiety disorders.
References
[1] L G MILLER. Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased gamma-aminobutyric acidA receptor function.[J]. Journal of Pharmacology and Experimental Therapeutics, 1988, 246 1: 170-176.
[2] DAVID BALDWIN. Efficacy of drug treatments for generalised anxiety disorder: systematic review and meta-analysis.[J]. BMJ : British Medical Journal, 2011: d1199. DOI: 10.1136/bmj.d1199
[3] BJOERN MOOSMANN Volker A Philippe Bisel. Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokinetics[J]. Drug Testing and Analysis, 2014, 6 7-8: 757-763. DOI: 10.1002/dta.1628