Lorazepam
Lorazepam Basic information
- Product Name:
- Lorazepam
- Synonyms:
-
- (±)-Lorazepam solution
- 8133 CB
- 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
- 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one
- Lorazepam CIV (200 mg)I1D4040.998mg/mg(ai)
- Lorazepam CIV (200 mg)
- Acetonitrile( Test Lorazepam, 1.0 mg/mL )
- LorazepaM (CIV), USP
- CAS:
- 846-49-1
- MF:
- C15H10Cl2N2O2
- MW:
- 321.16
- EINECS:
- 212-687-6
- Product Categories:
-
- API's
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Isotope Labeled Compounds
- Mol File:
- 846-49-1.mol
Lorazepam Chemical Properties
- Melting point:
- 166-168°C
- Boiling point:
- 533.8±50.0 °C(Predicted)
- Density
- 1.4835 (rough estimate)
- refractive index
- 1.6070 (estimate)
- Flash point:
- 11 °C
- storage temp.
- −20°C
- solubility
- Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride.
- pka
- pK1 1.3; pK2 11.5(at 25℃)
- Water Solubility
- 54mg/L(temperature not stated)
- BCS Class
- 1
- Stability:
- hygroscopic
- CAS DataBase Reference
- 846-49-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Lorazepam(846-49-1)
- EPA Substance Registry System
- Lorazepam (846-49-1)
Safety Information
- Hazard Codes
- Xn,T,F
- Risk Statements
- 63-39/23/24/25-23/24/25-11-36-20/21/22
- Safety Statements
- 36/37-45-16
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
- RTECS
- DF0350000
- HS Code
- 2933910000
- Toxicity
- LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen)
MSDS
- Language:English Provider:7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
- Language:English Provider:SigmaAldrich
Lorazepam Usage And Synthesis
Chemical Properties
White Crystalline Solid
Originator
Tavor,Wyeth,Italy,1972
Uses
An anxiolytic, and anticonvulsant. Controlled substance (depressant)
Definition
ChEBI: Lorazepam is a benzodiazepine.
Manufacturing Process
The starting material was 2-amino-2',5-dichlorobenzophenone which was
reacted with hydroxylamine and then with chloroacetyl chloride. The
intermediate thus obtained is reacted with methylamine and then with acetic
anhydride.
To a slightly warm suspension of 3-acetoxy-7-chloro-5-(o-chlorophenyl)-1,3-
dihydro-2H-1,4-benzodiazepin-2-one thus obtained was added 4N sodium
hydroxide solution with stirring. All the solid dissolved and soon a thick white
solid precipitated out. The solid was filtered, washed well with water and
recrystallized from ethanol. The product was isolated as a solvate with 1 mol
of ethanol. When heated it loses the ethanol of solvation and melts at 166°C
to 168°C.
brand name
Ativan (Baxter Healthcare); Ativan (Biovail); Loraz (Quantum Pharmics).
Therapeutic Function
Tranquilizer
General Description
Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity.
Biological Activity
Ligand at the GABA A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Lorazepam Preparation Products And Raw materials
Raw materials
Lorazepam(846-49-1)Related Product Information
- 4-Chlorophenyl isocyanate
- Triphenylmethyl Chloride
- Chlorodiphenylmethane
- Chlorodimethylphenylsilane
- CHLOROPHOSPHONAZO III
- Dihydromyrcenol
- LORMETAZEPAM
- Lorazepam
- NITROUS OXIDE
- Difluorochloromethane
- lorazepam acetate,Lorazepam 3-acetate
- Lorazepam7-Chloro-2-Oxo-5-(2-Chlorohenyl)-1,4-Benzodiazepine-4-Oxide
- LORAZEPAM IMPURITY A,LORAZEPAM IMP A
- LORAZEPAM RELATED COMPOUND D (25 MG) (6-CHLORO-4-(O-CHLOROPHENYL)-2-QUINAZOLINECAR-BOXYLIC ACID)
- LORAZEPAM [CONTROLLED SUBSTANCE]
- (S)-Lorazepam
- Lorazepam -D-Glucuronide
- (R)-Lorazepam