2,5-Dichlorobenzophenone Chemical Properties

Melting point:

87-88°C

Boiling point:

240-260 °C

Density 

1.311±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

crystals

color 

Off-white to brown

CAS DataBase Reference

16611-67-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

2914790090

2,5-Dichlorobenzophenone Usage And Synthesis

Uses

2,5-Dichlorobenzophenones can be used as starting materials for general, pharmaceutical and polymer synthesis. For example, using such compounds to prepare substituted para-polyphenylenes should proceed readily by metal-catalyzed aryl coupling of the 2,5-dichlorophenyl group of these compounds. Polyphenylenes formed from these compounds will have pendant side groups comprising the carbonyl, and the aryl or pyridyl group bonded thereto.

Synthesis

To a 22 L, three-necked flask fitted with a thermometer, mechanical stirrer and a Vigreux column connected to an aqueous NaOH scrubbing tower, was added 1,4-dichlorobenzene (3 Kg, 26.4 mol) and benzoyl chloride (2.6 Kg, 18.55 mol). The mixture was heated to 80° C. to give a homogeneous solution. Aluminum chloride (5.5 Kg, 41.25 mol) was added over 12 min. with stirring. (The molar ratio of reactants was 2.2:1.4:1.0 (AlCl3 : Dichlorobenzene: Benzoyl Chloride)). The resulting mixture was heated to 140° C. over 60 min, followed by heating to 175° C. over 30 min. The heating was stopped at 175° C. The mixture was allowed to cool to 80° C. over two hours and poured into a well-stirred mixture of ice and water (ca. 25 L water and 15 Kg of ice) over 30 min. The organic solid was collected by filtration and dissolved in 7 L of toluene. The solution was washed with aqueous sodium bicarbonate and dried. Toluene was removed by distillation. Pure 2,5-dichlorobenzophenone was isolated in 80% yield after recrystallization from hexane and toluene.

2,5-Dichlorobenzophenone(16611-67-9)Related Product Information

• Benzophenone hydrazone
• Benzophenone imine
• Benzophenone
• 4-Chlorobenzophenone
• Dichloroethane
• 1,2-Dichloroethane
• 1,4-DICHLOROANTHRAQUINONE
• 5,8-DICHLORO-1,4-DIHYDROXYANTHRAQUINONE
• dichlorobenzophenon
• p-dichlorobenzophenone,p,p-Dichlorobenzophenone,p,p’-dichlorobenzophenon
• 2,2''-DICHLOROBENZOPHENONE 98+%
• 3,4-Dichlorobenzophenone 99%,3,4-Dichlorobenzophenone,98%,3,4-Dichlorobenzophenone99%
• 2-(2-BROMOACETAMIDO)-2',5-DICHLOROBENZOPHENONE
• 5,5'-BIS(TRIFLUOROMETHYL)-2,2'-DICHLOROBENZOPHENONE
• 2-CHLOROACETYLAMIDO-2'',5-DICHLOROBENZOPHENONE,2-(2-CHLOROACETAMIDO)-2',5-DICHLOROBENZOPHENONE
• DICHLOROBENZOPHENONE(2,4-)
• 2-Amino-5,2''-Dichlorobenzophenone(CCAB),2-Amino-2',5-dichlorobenzophenone,99%,2-Amino-2-dichlorobenzophenone
• 2-AMINO-2',5'-DICHLOROBENZOPHENONE