4-Chlorobenzophenone Chemical Properties

Melting point:

74-76 °C (lit.)

Boiling point:

195-196 °C/17 mmHg (lit.)

Density 

1.1459 (rough estimate)

vapor pressure 

0.015Pa at 25℃

refractive index 

1.5260 (estimate)

Flash point:

143°C

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Powder

color 

White to off-white

Water Solubility 

20.706mg/L at 29℃

BRN 

512043

InChIKey

UGVRJVHOJNYEHR-UHFFFAOYSA-N

LogP

3.748 at 25℃

CAS DataBase Reference

134-85-0(CAS DataBase Reference)

NIST Chemistry Reference

Methanone, (4-chlorophenyl)phenyl-(134-85-0)

EPA Substance Registry System

Methanone, (4-chlorophenyl)phenyl- (134-85-0)

Safety Information

Hazard Codes 

Risk Statements 

Safety Statements 

WGK Germany 

2

RTECS 

AM5978800

F 

19

TSCA 

Yes

HS Code 

29147000

Hazardous Substances Data

134-85-0(Hazardous Substances Data)

MSDS

• Language:English Provider:4-Chlorobenzophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Chlorobenzophenone Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

UV curing type coating, printing ink, medical and pesticide intermediate

Uses

4-Chlorobenzophenone, is a building block used in various chemical synthesis. It can be used for the preparation of a variety of functionalized Coumarin derivatives.

Definition

ChEBI: 4-chlorobenzophenone is a member of benzophenones. It is a known transformation product of 1-[(4-Chlorophenyl)phenylmethyl]piperazine, Cetirizine, Cetirizine N-oxide, Chlorcyclizine, and Meclozine.

Synthesis Reference(s)

Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1

Toxicology

May cause SENSITISATION by skin contact. Irritating to eyes, respiratory system and skin. The material has NOT been classified as "harmful by ingestion".
This material can cause eye irritation and damage in some persons.
The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. 
Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled

Purification Methods

Recrystallise it from EtOH. [Wagner et al. J Am Chem Soc 108 7727 1986, Beilstein 7 H 419, 7 I 227, 7 II 359, 7 III 2072, 7 IV 1375.]

4-Chlorobenzophenone(134-85-0)Related Product Information

• Phenyl salicylate
• Benzophenone
• Acetaldehyde
• Benzophenone imine
• Diphenyl ether
• PHENYL VALERATE
• 2,2',4,4'-Tetrahydroxybenzophenone
• 3-CHLOROBENZOPHENONE
• 4-Hydroxybenzophenone
• PHENYL RESIN
• 2-Benzyl-2-(dimethylamino)-4'-morpholinobutyrophenone
• Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide
• 2-Isopropylthioxanthone
• 2,2-Diethoxyacetophenone
• Ethyl 4-dimethylaminobenzoate
• Ethyl (2,4,6-trimethylbenzoyl) phenylphosphinate
• 4-CHLORODIPHENYLAMINE
• N-(2,4-Dichlorophenyl)benzenamine