Ethyl diphenylphosphinite Chemical Properties

Melting point:

164-167 °C(Solv: heptane (142-82-5); benzene (71-43-2))

Boiling point:

179-180 °C (14 mmHg)

Density 

1.066 g/mL at 25 °C (lit.)

vapor pressure 

0.124-0.35Pa at 20-25℃

refractive index 

n20/D 1.59(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Soluble in chloroform.

form 

clear liquid

Specific Gravity

1.066

color 

Colorless to Light yellow

Sensitive 

Air & Moisture Sensitive

BRN 

1641750

InChIKey

JCRCPEDXAHDCAJ-UHFFFAOYSA-N

LogP

3.595-5.57 at 25℃

CAS DataBase Reference

719-80-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

RTECS 

211-951-8

PackingGroup 

III

HS Code 

29319090

MSDS

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Ethyl diphenylphosphinite Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Uses

Ethyl diphenylphosphinite is used in the synthesis of phosphoramides.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling

Synthesis

Example 2: 330 g (7.17 mol) of anhydrous ethanol was cooled to -15°C under nitrogen protection. Subsequently, 18 g (1.06 mol) of ammonia was passed at this temperature. Next, 200 g (0.907 mol) of diphenylphosphonium chloride was slowly added dropwise over a period of 1 hour. After the dropwise addition was completed, the reaction mixture was gradually warmed to room temperature with stirring and stirring was continued for 3.5 hours. After completion of the reaction, the mixture was cooled, diafiltrated and the solids were washed with ethanol. The filtrate was treated to ensure that it was free of ethanol and residual ammonia. A small amount of precipitate was removed by filtration through glass material. Finally, purification by thin film distillation at a bath temperature of 140 °C and pressure of 0.3 mbar gave 172 g of ethoxydiphenylphosphine in 83% yield of the theoretical value.

References

[1] Patent: US5705669, 1998, A
[2] Patent: US5705669, 1998, A
[3] Patent: US5705669, 1998, A
[4] Patent: US5705669, 1998, A
[5] J. Gen. Chem. USSR (Engl. Transl.), 1961, vol. 31, p. 2214 - 2217

Ethyl diphenylphosphinite(719-80-2)Related Product Information

• tert-Butylchlorodiphenylsilane
• Ethoxyethyne
• Ethoxyquin
• Diphenylphosphine
• Phenetidine
• Ethyl formate
• Ethyl propionate
• Ethanol
• Ethyl vanillin
• Chlorodiphenylphosphine
• DIETHOXYMETHANE
• Ethylbenzene
• 2-Ethoxyphenol
• Ethylparaben
• Ethyl acetate
• Ethyl acrylate
• Diethyl ether
• 1R,5R,6R-(+)-1,6-BIS(DIPHENYLPHOSPHINOXY)SPIRO[4.4]NONANE