(+)-ALPHA-DIHYDROTETRABENAZINE Chemical Properties

Boiling point:

457.8±45.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Chloroform: soluble; Methanol: soluble

form 

A solid

pka

14.75±0.40(Predicted)

CAS DataBase Reference

3466-75-9

(+)-ALPHA-DIHYDROTETRABENAZINE Usage And Synthesis

Description

Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (K_ds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC₅₀s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (K_ds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.

Chemical Properties

Colourless solid

Definition

ChEBI: B-Dihydrotetrabenazine is a member of isoquinolines.

(+)-ALPHA-DIHYDROTETRABENAZINE(3466-75-9)Related Product Information

• Butylphthalide
• HOMOCALYCOTOMINE
• (+)-9-O-DESMETHYL-ALPHA-DIHYDROTETRABENAZINE
• (+)-ALPHA-DIHYDROTETRABENAZINE