1H-INDOLE-6-METHANAMINE Chemical Properties

Melting point:

135-140℃

Boiling point:

335.6±17.0 °C(Predicted)

Density 

1.199±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

17.21±0.30(Predicted)

Appearance

Off-white to light yellow Solid

Water Solubility 

Slightly soluble in water.

Sensitive 

Moisture Sensitive

CAS DataBase Reference

3468-17-5

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933998090

1H-INDOLE-6-METHANAMINE Usage And Synthesis

Uses

6-(Aminomethyl)indole is used as an organic chemical synthesis intermediate.

Synthesis

Example 71 Preparation of 1H-indole-6-methylamine: 1H-indole-6-carbonitrile (prepared by literature methods: Batcho, AD; Leimgruber, W. Organic Syntheses 1985, 63, 214-225; 1.50 g, 10.6 mmol) was hydrogenated overnight at atmospheric pressure over a nickel Nguyenne catalyst in a mixture of ethanol (50 mL) and concentrated ammonia (4 mL). (4 mL) in a mixed solution of ethanol (50 mL) and concentrated ammonia (4 mL) at atmospheric pressure overnight for hydrogenation. Upon completion of the reaction, the reaction mixture was filtered through Celite to remove the catalyst. The filter cake was washed well with ethanol, taking care to avoid drying of the catalyst. The filtrates were combined and concentrated to afford 1H-indole-6-methylamine (1.50 g, 97% yield).

References

[1] Patent: US2002/161237, 2002, A1

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