5,6-DICHLOROBENZIMIDAZOLE-2-THIOL Chemical Properties

Melting point:

300 °C

Boiling point:

329.8±52.0 °C(Predicted)

Density 

1.68±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

8.76±0.30(Predicted)

Appearance

White to off-white Solid

Water Solubility 

Insoluble in water.

CAS DataBase Reference

19462-98-7

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-37

HS Code 

2933998090

MSDS

• Language:English Provider:ALFA

5,6-DICHLOROBENZIMIDAZOLE-2-THIOL Usage And Synthesis

Uses

It is employed in the synthesis of 2?,3?-dideoxy and 2?,3?-unsaturated ribofuranonucleosides as potential antiviral agents.

Synthesis

GENERAL METHOD: 4,5-Dichloro-1,2-phenylenediamine (0.065 mol) was heated to reflux with N-amino winding tannin (0.065 mol) in xylene (50 mL) for 5 hours. After completion of the reaction, it was cooled to room temperature and the precipitate was collected by filtration. The crude product was purified by thermal crystallization using aqueous ethanol (containing activated carbon). The resulting solid was further recrystallized in ethanol to give 2-mercapto-5,6-dichlorobenzimidazole.

References

[1] Oriental Journal of Chemistry, 2016, vol. 32, # 4, p. 1765 - 1768

5,6-DICHLOROBENZIMIDAZOLE-2-THIOL(19462-98-7)Related Product Information

• 2-Mercaptobenzimidazole
• 5,6-DICHLOROBENZIMIDAZOLE
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• 1H-BENZOIMIDAZOLE-2-THIOL
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