4-(Trifluoromethoxy)benzaldehyde Chemical Properties

Boiling point:

93 °C27 mm Hg(lit.)

Density 

1.331 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.458(lit.)

Flash point:

159 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Liquid

Specific Gravity

1.331

color 

Clear colorless to pale yellow-green

Sensitive 

Air Sensitive

BRN 

1949135

InChI

InChI=1S/C8H5F3O2/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-5H

InChIKey

XQNVDQZWOBPLQZ-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(OC(F)(F)F)C=C1

CAS DataBase Reference

659-28-9(CAS DataBase Reference)

NIST Chemistry Reference

Benzaldehyde, 4-(trifluoromethoxy)-(659-28-9)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-36/38-22

Safety Statements 

26-36/37/39-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29130000

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:4-(Trifluoromethoxy)benzaldehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-(Trifluoromethoxy)benzaldehyde Usage And Synthesis

Chemical Properties

clear colorless to pale yellow-green liquid

Uses

4-(Trifluoromethoxy)benzaldehyde is suitable for use in the synthesis of (E)-4-(trifluoromethoxy)benzaldehyde thiosemicarbazone. It may be used in the synthesis of:

• new azo dyes containing of 5(4H)-oxazolone ring
• 2-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole
• (E)-2-[4-(trifluoromethoxy)benzylidene]indan-1-one.

General Description

4-(Trifluoromethoxy)benzaldehyde (p-(trifluoromethoxy)benzaldehyde) is an aromatic aldehyde. It participates in the synthesis of 4,5-dihydro-4-(4-trifluoromethoxyphenyl)pyrrolo[1,2-a]quinoxaline.

Synthesis

In a flask with a reflux condenser and an inlet tube, 3.62 g of 4-trifluoromethoxybromobenzene, 0.21 g of bis(triphenylphosphine)palladium dichloride, and 1.53 g of sodium formate were added with 15 ml of DMF were mixed, stirred and heated to 110 ??C under the condition that CO was passed. After completion of the reaction (GC), the reaction mixture was cooled to 21 ??C and separated from the catalyst by silica gel filtration. . The crude product obtained contained 91% p-trifluoromethoxybenzaldehyde and 7% 4-trifluoromethoxybenzyl alcohol (percentages based on area ratio in GC).

4-(Trifluoromethoxy)benzaldehyde(659-28-9)Related Product Information

• 4-(Trifluoromethoxy)benzaldehyde
• 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE
• 4-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE
• 4-(Trifluoromethoxy)benzoic acid
• 4'-(Trifluoromethoxy)acetophenone
• METHYL 4-(TRIFLUOROMETHOXY)BENZOATE
• 4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE
• 4-(TRIFLUOROMETHOXY)BENZAMIDE
• 3-Chloro-4-(trifluoromethoxy)benzoic acid
• 4-METHOXY-3-(TRIFLUOROMETHOXY)BENZALDEHYDE
• 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
• 5-fluoro-2-trifluoromethoxybenzaldehyde
• 4-Bromo-2-(trifluoromethoxy)benzaldehyde
• 2-FLUORO-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
• 2-HYDROXY-3-(TRIFLUOROMETHOXY)BENZALDEHYDE
• 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
• 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
• 3-(TRIFLUOROMETHOXY)BENZALDEHYDE 95,3-(Trifluoromethoxy)benzaldehyde,3-(Trifluoromethoxy)benzaldehyde 97%,3-(Trifluoromethoxy)benzaldehyde97%