5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Chemical Properties

Boiling point:

335.0±42.0 °C(Predicted)

Density 

1.692±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

3.48±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Synthesis

5-Bromo-4-methyl-2-vinylpyridine (600 mg, 3 mmol) was used as raw material and dissolved in a solvent mixture of acetone-water (1:1, 54 mL). Subsequently, potassium permanganate (KMnO4, 957 mg, 6 mmol) was added to this solution. The reaction mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the mixture was filtered to remove insoluble impurities, and the filtrate was concentrated and purified by column chromatography to give 5-bromo-4-methylpyridine-2-carboxylic acid (700 mg, 92% yield) as a white solid.

References

[1] Patent: US2011/71150, 2011, A1. Location in patent: Page/Page column 33-34
[2] Patent: US2013/158040, 2013, A1. Location in patent: Paragraph 0134
[3] Patent: US2013/158049, 2013, A1. Location in patent: Paragraph 0168
[4] Patent: US2013/158066, 2013, A1. Location in patent: Paragraph 0134
[5] Patent: WO2012/143329, 2012, A1

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