4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

137-141 °C

Boiling point:

307.4±22.0 °C(Predicted)

Density 

1.230±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

1.11±0.50(Predicted)

color 

White to Light yellow

CAS DataBase Reference

4021-08-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29333990

4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White to light brown solid

Uses

4-Methylpyridine-2-carboxylic acid is a used in biological studies for the mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A.

Synthesis

General procedure for the synthesis of 4-methylpyridine-2-carboxylic acid from 2-cyano-4-methylpyridine: 2-cyano-4-methylpyridine (0.15 g, 1.27 mmol) was dissolved in about 10 mL of 6 M hydrochloric acid and heated and refluxed for 24 hours. During the reaction, the solution gradually changed from the initial pale yellow color to clear. Upon completion of the reaction, the solution was evaporated to dryness to give a white solid product. Purification by recrystallization from a minimal amount of distilled water resulted in 148 mg (85% yield) of 4-methylpyridine-2-carboxylic acid. The product was characterized by 1H NMR (DMSO-d6): δ = 8.65 (1H, s), 8.06 (1H, s), 7.66 (1H, s), 2.05 (3H, s).

References

[1] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 49
[2] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 49
[3] Patent: US5219847, 1993, A
[4] Advanced Synthesis and Catalysis, 2013, vol. 355, # 5, p. 947 - 956
[5] Patent: US6251919, 2001, B1

4-METHYL-PYRIDINE-2-CARBOXYLIC ACID(4021-08-3)Related Product Information

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