PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Chemical Properties

Melting point:

246-248 °C (dec.)(lit.)

storage temp. 

Store at -20°C

solubility 

DMSO: 1.4 mg/ml; PBS (pH 7.2): 0.2 mg/ml

form 

A crystalline solid

BRN 

131631

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Usage And Synthesis

Description

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC₅₀ = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.

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