4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester Chemical Properties

form 

Solid

color 

Orange to red

4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester Usage And Synthesis

Uses

PQQ-trimethylester (PQQ-TME) is a synthetic compound that is a trimethylester derivative of pyrroloquinoline quinone (PQQ). PQQ-trimethylester has twice the blood-brain barrier permeability of PQQ (HY-100196) in vitro. In addition, PQQ-trimethylester shows strong inhibitory activity against α-synuclein, amyloid β1-42 (Aβ1-42) and prion protein fibrillation. PQQ-trimethylester can be used in the study of neurodegenerative diseases[1].

IC 50

α-synuclein Aggregation

References

[1] Tsukakoshi K, et al. Esterification of PQQ enhances blood-brain barrier permeability and inhibitory activity against amyloidogenic protein fibril formation[J]. ACS Chemical Neuroscience, 2018, 9(12): 2898-2903. DOI:10.1021/acschemneuro.8b00355

4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester(74447-88-4)Related Product Information

• 2,6-DIMETHYLISONICOTINIC ACID
• (6-ethylpyridin-2-yl)methanol
• 4-Acetyl-1H-pyrrole-2-carboxylic acid
• 2-Pyridinecarboxaldehyde, 6-acetyl- (9CI)
• 2-Acetyl-4-methylpyridine
• 1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE
• 2,4-Pyridinedicarboxylic acid
• 2-Pyridinecarboxylicacid,6-ethyl-(9CI)
• 7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-1H-PYRROLO-[2,3-F]QUINOLINE-4,5-DIONE
• 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI)
• Dimethyl 2,4-pyridinedicarboxylate
• methyl 6-methylpyridine-2-carboxylate
• 6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER
• b-Nornicotyrine
• PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE
• 2-Acetylisonicotinic acid
• (2,6-DIMETHYLPYRIDIN-4-YL)METHANOL
• 1-(3-METHYLPYRIDIN-2-YL)ACETONE