4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester

Product Name: 4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester
CAS No.: 74447-88-4
Chemical Name: 4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester
Synonyms: PQQ-TME;Pqq trimethyl ester;Methoxatin trimethyl ester;Coenzyme pqq trimethyl ester;Trimethyl 4,5-dihydro-4,5-dioxo-1H-pyrrolo(2,3-F)quinoline-2,7,9-tricarboxylate;4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester;1H-Pyrrolo(2,3-F)quinoline-2,7,9-tricarboxylic acid, 4,5-dihydro-4,5-dioxo-, trimethyl ester;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester
CBNumber: CB81118357
Molecular Formula: C17H12N2O8
Formula Weight: 372.28578
MOL File: 74447-88-4.mol

More

Less

4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester Property

form: Solid
color: Orange to red

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester Chemical Properties,Usage,Production

Uses

PQQ-trimethylester (PQQ-TME) is a synthetic compound that is a trimethylester derivative of pyrroloquinoline quinone (PQQ). PQQ-trimethylester has twice the blood-brain barrier permeability of PQQ (HY-100196) in vitro. In addition, PQQ-trimethylester shows strong inhibitory activity against α-synuclein, amyloid β1-42 (Aβ1-42) and prion protein fibrillation. PQQ-trimethylester can be used in the study of neurodegenerative diseases[1].

IC 50

α-synuclein Aggregation

References

[1] Tsukakoshi K, et al. Esterification of PQQ enhances blood-brain barrier permeability and inhibitory activity against amyloidogenic protein fibril formation[J]. ACS Chemical Neuroscience, 2018, 9(12): 2898-2903. DOI:10.1021/acschemneuro.8b00355

4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester Suppliers

China 2 United States 3 Global 5

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29496
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co.,Ltd.

Tel: 0751-2815983 13927872582
Fax: 0751-2886750
Email: 2787852318@qq.com
Country: China
ProdList: 8050
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

74447-88-4, 4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl esterRelated Search:

2,6-DIMETHYLISONICOTINIC ACID (6-ethylpyridin-2-yl)methanol 4-Acetyl-1H-pyrrole-2-carboxylic acid 2-Pyridinecarboxaldehyde, 6-acetyl- (9CI) 2-Acetyl-4-methylpyridine 1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE 2,4-Pyridinedicarboxylic acid 2-Pyridinecarboxylicacid,6-ethyl-(9CI) 7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-1H-PYRROLO-[2,3-F]QUINOLINE-4,5-DIONE 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI) Dimethyl 2,4-pyridinedicarboxylate methyl 6-methylpyridine-2-carboxylate 6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER b-Nornicotyrine PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE 2-Acetylisonicotinic acid (2,6-DIMETHYLPYRIDIN-4-YL)METHANOL 1-(3-METHYLPYRIDIN-2-YL)ACETONE

4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester

4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester

1H-Pyrrolo(2,3-F)quinoline-2,7,9-tricarboxylic acid, 4,5-dihydro-4,5-dioxo-, trimethyl ester

Coenzyme pqq trimethyl ester

Methoxatin trimethyl ester

Pqq trimethyl ester

Trimethyl 4,5-dihydro-4,5-dioxo-1H-pyrrolo(2,3-F)quinoline-2,7,9-tricarboxylate

PQQ-TME

74447-88-4

C17H12N2O8