6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER Chemical Properties

Melting point:

94-98 °C

Boiling point:

296.6±25.0 °C(Predicted)

Density 

1.249±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

1.57±0.10(Predicted)

Appearance

White to light yellow Solid

InChI

InChI=1S/C8H7NO3/c1-12-8(11)7-4-2-3-6(5-10)9-7/h2-5H,1H3

InChIKey

CERBENZCBVYKEF-UHFFFAOYSA-N

SMILES

C1(C(OC)=O)=NC(C=O)=CC=C1

Safety Information

HS Code 

2933399990

6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER Usage And Synthesis

Synthesis

General procedure for the synthesis of methyl 6-formyl-2-pyridinecarboxylate from methyl 6-hydroxymethyl-2-pyridinecarboxylate: the product of Example 17A (8 g, 48 mmol) was dissolved in dichloromethane (200 mL) and electrolytic manganese dioxide (41.67 g, 0.48 mol) was added. The reaction mixture was stirred at 25 °C for 4 days and filtered through diatomaceous earth after completion of the reaction. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to afford methyl 6-formyl-2-pyridinecarboxylate as a white solid (6.9 g, 87% yield) using a 5% dichloromethane solution of methanol as eluent.

References

[1] Patent: US2005/131017, 2005, A1. Location in patent: Page/Page column 106
[2] Patent: US6020345, 2000, A
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 609 - 612
[4] Patent: WO2004/37808, 2004, A1. Location in patent: Page 9-10
[5] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 2, p. 161 - 168

6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER(69950-65-8)Related Product Information

• 6-METHOXY-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER
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