2,4-DIETHYLPYRIDINE DICARBOXYLATE Chemical Properties

Melting point:

31 °C

Boiling point:

330.9±22.0 °C(Predicted)

Density 

1.165±0.06 g/cm3(Predicted)

vapor pressure 

0.022Pa at 25℃

storage temp. 

2-8°C

solubility 

≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide

pka

-0.69±0.10(Predicted)

form 

Crystalline

color 

White to Almost white

LogP

1.92 at 20℃ and pH7.82

Surface tension

56.3mN/m at 1g/L and 19.7℃

CAS DataBase Reference

41438-38-4

Safety Information

HS Code 

2933.39.9200

2,4-DIETHYLPYRIDINE DICARBOXYLATE Usage And Synthesis

Biological Activity

2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1].

References

[1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.
[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626.

2,4-DIETHYLPYRIDINE DICARBOXYLATE(41438-38-4)Related Product Information

• 2-FORMYL-4-PICOLINE
• 2,4-DIETHYLPYRIDINE DICARBOXYLATE
• Ethyl isonicotinate
• Ethyl picolinate
• 4-METHYL-PYRIDINE-2-CARBOXYLIC ACID
• 2,4-Pyridinedicarboxylic acid
• 2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI)
• CHEMPACIFIC 38149
• 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI)
• Dimethyl 2,4-pyridinedicarboxylate
• 2 -METHYLISONICOTINIC ACID ETHYL ESTER
• 2,4-PYRIDINECARBOXYLIC ACID, 4-METHYL ESTER
• 2-methyl-4-pyridinecarboxylic acid methyl ester
• 4-METHYL-PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• 2-(ETHOXYCARBONYL)ISONICOTINIC ACID
• 4-(ETHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID