2,4-DIETHYLPYRIDINE DICARBOXYLATE

Product Name: 2,4-DIETHYLPYRIDINE DICARBOXYLATE
CAS No.: 41438-38-4
Chemical Name: 2,4-DIETHYLPYRIDINE DICARBOXYLATE
Synonyms: 2,4-DPD;Ai3-17897;Diethyl-2,4-pdc;2,4-Pdc diethyl ester;2,4-Pyridinedicarboxylic;DIETHYL 2,4-PYRIDINECARBOXYLATE;2,4-DIETHYLPYRIDINE DICARBOXYLATE;Diethyl 2,4-pyridinedicarboxylate;diethyl pyridine-2,4-dicarboxylate;diethyl 2,4-pyridinedicarboxylic acid
CBNumber: CB1454066
Molecular Formula: C11H13NO4
Formula Weight: 223.23
MOL File: 41438-38-4.mol

More

Less

2,4-DIETHYLPYRIDINE DICARBOXYLATE Property

Melting point:: 31 °C
Boiling point:: 330.9±22.0 °C(Predicted)
Density: 1.165±0.06 g/cm3(Predicted)
vapor pressure: 0.022Pa at 25℃
storage temp.: 2-8°C
solubility: ≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
pka: -0.69±0.10(Predicted)
form: Crystalline
color: White to Almost white
InChI: InChI=1S/C11H13NO4/c1-3-15-10(13)8-5-6-12-9(7-8)11(14)16-4-2/h5-7H,3-4H2,1-2H3
InChIKey: MUUDQLHCIAOWPR-UHFFFAOYSA-N
SMILES: C1(C(OCC)=O)=NC=CC(C(OCC)=O)=C1
LogP: 1.92 at 20℃ and pH7.82
Surface tension: 56.3mN/m at 1g/L and 19.7℃
CAS DataBase Reference: 41438-38-4

More

Less

Safety

HS Code: 2933.39.9200

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D5518
Product name: Diethyl 2,4-Pyridinedicarboxylate
Purity: >97.0%(GC)
Packaging: 200mg
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: D5518
Product name: Diethyl 2,4-Pyridinedicarboxylate
Purity: >97.0%(GC)
Packaging: 1g
Price: $169
Updated: 2025/07/31

Cayman Chemical

Product number: 71200
Product name: 2,4-DPD
Purity: ≥98%
Packaging: 10mg
Price: $19
Updated: 2024/03/01

Cayman Chemical

Product number: 71200
Product name: 2,4-DPD
Purity: ≥98%
Packaging: 25mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 71200
Product name: 2,4-DPD
Purity: ≥98%
Packaging: 50mg
Price: $78
Updated: 2024/03/01

More

Less

2,4-DIETHYLPYRIDINE DICARBOXYLATE Chemical Properties,Usage,Production

Uses

Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor. Diethyl pyridine-2,4-dicarb inhibits prolyl hydroxylation and procollagen processing in chick-embryo calvaria[1].

Biological Activity

2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1].

References

[1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.
[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626.

2,4-DIETHYLPYRIDINE DICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2,4-DIETHYLPYRIDINE DICARBOXYLATE Suppliers

Americas 1 China 89 Europe 1 Germany 1 India 2 Italy 1 Japan 1 Switzerland 2 United Kingdom 3 United States 10 Global 111

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Hao Yun Chemical Science Co.,Ltd.

Tel: 021-68367562 15002147577;
Fax: 021-68369562
Email: sales@haoyunchem.com
Country: China
ProdList: 457
Advantage: 55

Nanjing ShengSai Chemical Co., Ltd.

Tel: 025-85205967 13951876367
Fax: 025-85205967
Email: shengsaichem@163.com
Country: China
ProdList: 818
Advantage: 58

More

Less

View Lastest Price from 2,4-DIETHYLPYRIDINE DICARBOXYLATE manufacturers

Shenzhen Nexconn Pharmatechs Ltd

Product: Diethyl pyridine-2,4-dicarboxylate 41438-38-4
Price: US $1.00-10.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%+
Supply Ability: 1 ton
Release date: 2024-04-18

41438-38-4, 2,4-DIETHYLPYRIDINE DICARBOXYLATERelated Search:

2-FORMYL-4-PICOLINE 2,4-DIETHYLPYRIDINE DICARBOXYLATE Ethyl isonicotinate Ethyl picolinate 4-METHYL-PYRIDINE-2-CARBOXYLIC ACID 2,4-Pyridinedicarboxylic acid 2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI) CHEMPACIFIC 38149 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI) Dimethyl 2,4-pyridinedicarboxylate 2 -METHYLISONICOTINIC ACID ETHYL ESTER 2,4-PYRIDINECARBOXYLIC ACID, 4-METHYL ESTER 2-methyl-4-pyridinecarboxylic acid methyl ester 4-METHYL-PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 2-(ETHOXYCARBONYL)ISONICOTINIC ACID 4-(ETHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID

DIETHYL 2,4-PYRIDINECARBOXYLATE

Diethyl 2,4-pyridinedicarboxylate

2,4-Pyridinedicarboxylic acid, diethyl ester Pyridine-2,4-Dicarboxylic Acid Diethyl Ester

2,4-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

2,4-DPD

2,4-DIETHYLPYRIDINE DICARBOXYLATE

2,4-Pyridinedicarboxylic

2,4-pyridinedicarboxylicacid,ethylester

diethyl 2,4-pyridinedicarboxylic acid

2,4-Pdc diethyl ester

Ai3-17897

Diethyl-2,4-pdc

diethyl pyridine-2,4-dicarboxylate

2,4-pyridine dicarboxylic acid 2,4-diethyl ester

2,4-DIETHYL PYRIDINE-2,4-DICARBOXYLATE

pyridine-2,4-dicarboxylic acid diethyl ester

Collagen formation,Diethyl ester,Chick-embryo calvaria,2,4DPD,inhibit,Inhibitor,Prolyl hydroxylation,2,4 DPD,Procollagen

41438-38-4

Pyridines, Pyrimidines, Purines and Pteredines