ChemicalBook > CAS DataBase List > 2,4-DIETHYLPYRIDINE DICARBOXYLATE

2,4-DIETHYLPYRIDINE DICARBOXYLATE

Product Name
2,4-DIETHYLPYRIDINE DICARBOXYLATE
CAS No.
41438-38-4
Chemical Name
2,4-DIETHYLPYRIDINE DICARBOXYLATE
Synonyms
2,4-DPD;Ai3-17897;Diethyl-2,4-pdc;2,4-Pdc diethyl ester;2,4-Pyridinedicarboxylic;DIETHYL 2,4-PYRIDINECARBOXYLATE;2,4-DIETHYLPYRIDINE DICARBOXYLATE;Diethyl 2,4-pyridinedicarboxylate;diethyl pyridine-2,4-dicarboxylate;diethyl 2,4-pyridinedicarboxylic acid
CBNumber
CB1454066
Molecular Formula
C11H13NO4
Formula Weight
223.23
MOL File
41438-38-4.mol
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2,4-DIETHYLPYRIDINE DICARBOXYLATE Property

Melting point:
31 °C
Boiling point:
330.9±22.0 °C(Predicted)
Density 
1.165±0.06 g/cm3(Predicted)
vapor pressure 
0.022Pa at 25℃
storage temp. 
2-8°C
solubility 
≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
pka
-0.69±0.10(Predicted)
form 
Crystalline
color 
White to Almost white
LogP
1.92 at 20℃ and pH7.82
Surface tension
56.3mN/m at 1g/L and 19.7℃
CAS DataBase Reference
41438-38-4
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Safety

HS Code 
2933.39.9200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5518
Product name
Diethyl 2,4-Pyridinedicarboxylate
Purity
>97.0%(GC)
Packaging
200mg
Price
$62
Updated
2024/03/01
TCI Chemical
Product number
D5518
Product name
Diethyl 2,4-Pyridinedicarboxylate
Purity
>97.0%(GC)
Packaging
1g
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
71200
Product name
2,4-DPD
Purity
≥98%
Packaging
10mg
Price
$19
Updated
2024/03/01
Cayman Chemical
Product number
71200
Product name
2,4-DPD
Purity
≥98%
Packaging
25mg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
71200
Product name
2,4-DPD
Purity
≥98%
Packaging
50mg
Price
$78
Updated
2024/03/01
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2,4-DIETHYLPYRIDINE DICARBOXYLATE Chemical Properties,Usage,Production

Biological Activity

2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1].

References

[1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.
[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626.

2,4-DIETHYLPYRIDINE DICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DIETHYLPYRIDINE DICARBOXYLATE Suppliers

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View Lastest Price from 2,4-DIETHYLPYRIDINE DICARBOXYLATE manufacturers

Shenzhen Nexconn Pharmatechs Ltd
Product
Diethyl pyridine-2,4-dicarboxylate 41438-38-4
Price
US $1.00-10.00/kg
Min. Order
0.10000000149011612kg
Purity
98%+
Supply Ability
1 ton
Release date
2024-04-18

41438-38-4, 2,4-DIETHYLPYRIDINE DICARBOXYLATERelated Search:

2-FORMYL-4-PICOLINE 2,4-DIETHYLPYRIDINE DICARBOXYLATE Ethyl isonicotinate Ethyl picolinate 4-METHYL-PYRIDINE-2-CARBOXYLIC ACID 2,4-Pyridinedicarboxylic acid 2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI) CHEMPACIFIC 38149 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI) Dimethyl 2,4-pyridinedicarboxylate 2 -METHYLISONICOTINIC ACID ETHYL ESTER 2,4-PYRIDINECARBOXYLIC ACID, 4-METHYL ESTER 2-methyl-4-pyridinecarboxylic acid methyl ester 4-METHYL-PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 2-(ETHOXYCARBONYL)ISONICOTINIC ACID 4-(ETHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID

  • DIETHYL 2,4-PYRIDINECARBOXYLATE
  • Diethyl 2,4-pyridinedicarboxylate
  • 2,4-Pyridinedicarboxylic acid, diethyl ester Pyridine-2,4-Dicarboxylic Acid Diethyl Ester
  • 2,4-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
  • 2,4-DPD
  • 2,4-DIETHYLPYRIDINE DICARBOXYLATE
  • 2,4-Pyridinedicarboxylic
  • 2,4-pyridinedicarboxylicacid,ethylester
  • diethyl 2,4-pyridinedicarboxylic acid
  • 2,4-Pdc diethyl ester
  • Ai3-17897
  • Diethyl-2,4-pdc
  • diethyl pyridine-2,4-dicarboxylate
  • 2,4-pyridine dicarboxylic acid 2,4-diethyl ester
  • 2,4-DIETHYL PYRIDINE-2,4-DICARBOXYLATE
  • pyridine-2,4-dicarboxylic acid diethyl ester
  • Collagen formation,Diethyl ester,Chick-embryo calvaria,2,4DPD,inhibit,Inhibitor,Prolyl hydroxylation,2,4 DPD,Procollagen
  • 41438-38-4
  • Pyridines, Pyrimidines, Purines and Pteredines