Thailanstatin C
Thailanstatin C Basic information
- Product Name:
- Thailanstatin C
- Synonyms:
-
- Thailanstatin C
- 2H-Pyran-2-acetic acid, 4-(chloromethyl)tetrahydro-4,5-dihydroxy-6-[(1E,3E)-3-methyl-5-[(2S,3S,5R,6R)-tetrahydro-3,6-dimethyl-5-[[(2Z,4S)-4-(2-methyl-1-oxopropoxy)-1-oxo-2-penten-1-yl]amino]-2H-pyran-2-yl]-1,3-pentadien-1-yl]-, (2S,4S,5R,6R)-
- 2-[(2S,4S,5R,6R)-4-(chloromethyl)-6-[(1E,3E)-5-[(2S,3S,5R,6R)-3,6-dimethyl-5-[(2Z,4S)-4-[(2-methylpropanoyl)oxy]pent-2-enamido]oxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-4,5-dihydroxyoxan-2-yl]acetic acid
- CAS:
- 1426953-24-3
- MF:
- C30H46ClNO9
- MW:
- 600.14
- Product Categories:
-
- ADC
- Mol File:
- 1426953-24-3.mol
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Thailanstatin C Chemical Properties
- Boiling point:
- 776.9±60.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- pka
- 4.38±0.10(Predicted)
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Thailanstatin C Usage And Synthesis
Uses
Thailanstatin C is a pre-mRNA splicing inhibitor (IC50= 6.84 μM) and antiproliferative agent from Burkholderia thailandensis MSMB43[1].
References
[1] Liu X, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013;76(4):685-693. DOI:10.1021/np300913h
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