Thailanstatin D
Thailanstatin D Basic information
- Product Name:
- Thailanstatin D
- Synonyms:
-
- Thailanstatin D
- 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-, (3S,5S,7S)-
- 2-[(3S,5S,7S)-7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[(2Z,4S)-4-(acetyloxy)pent-2-enamido]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dien-1-yl]-1,6-dioxaspiro[2.5]octan-5-yl]acetic acid
- CAS:
- 1609105-89-6
- MF:
- C28H41NO8
- MW:
- 519.63
- Product Categories:
-
- ADC
- Mol File:
- 1609105-89-6.mol
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Thailanstatin D Chemical Properties
- Boiling point:
- 722.3±60.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- pka
- 4.37±0.10(Predicted)
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Thailanstatin D Usage And Synthesis
Uses
Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis[1].
in vivo
Thailanstatin D (300 μg/kg; ALZET osmotic pumps; daily for 4 days) significantly inhibits the tumor growth[1].
| Animal Model: | NOD-SCID mice ( Mice bearing 22RV1 xenografts)[1] |
| Dosage: | 300 μg/kg |
| Administration: | ALZET osmotic pumps; daily for 4 days |
| Result: | Significantly inhibited the tumor growth. |
References
[1] Wang B, et al. Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer. Int J Cancer. 2017;141(10):2121-2130. DOI:10.1002/ijc.30893
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