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Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate

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Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Basic information

Product Name:
Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate
Synonyms:
  • n-[[5-(methylamino)-2-thienyl]carbonyl]-l-glutamic acid diethyl ester
  • diethyl n-[5-methylamino-2-thenoyl]-l-glutamate
  • (S)-Diethyl 2-(5-(MethylaMino)thiophene-2-carboxaMido)pentanedioate
  • L-Glutamic acid, N-[[5-(methylamino)-2-thienyl]carbonyl]-, 1,5-diethyl ester
  • iethyl(2S)-2-[[5-(methylamino)thiophene-2-carbonyl]amino]pentanedioate
  • Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate USP/EP/BP
  • Raltitrexed Impurity 24
CAS:
112889-02-8
MF:
C15H22N2O5S
MW:
342.41
Product Categories:
  • Raltitrexed
Mol File:
112889-02-8.mol
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Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Chemical Properties

Boiling point:
519.6±50.0 °C(Predicted)
Density 
1.231
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
12.89±0.46(Predicted)
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Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Usage And Synthesis

Uses

N-[[5-(Methylamino)-2-thienyl]carbonyl]-L-glutamic Acid Diethyl Ester can be used as reactant/reagent for synthetic preparation of Raltitrexed (anticancer agent). An intermediate or impurity in the synthesis of Raltitrexed (R100500). Raltitrexed (R100500) is folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic.

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