bromchlorenone Chemical Properties

Melting point:

204.5°C

Density 

1.8508 (rough estimate)

refractive index 

1.6110 (estimate)

bromchlorenone Usage And Synthesis

Uses

Anti-infective, topical.

Synthesis

2-Amino-5-bromo-4-chlorophenol (Intermediate 7, 8.4 g, 37.8 mmol) and N,N'-carbonyldiimidazole (12.2 g, 75.6 mmol) were used as raw materials and reacted in THF (250 mL) for 3 hours at 80 °C. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography (200-400 mesh, 100 g) with petroleum ether/ethyl acetate as eluent (gradient from 9:1 to 5:1) to afford 6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one as an orange solid (7.7 g, 82% yield).LCMS (Method A): retention time 1.49 min, molecular ion peak m/z 248 /250 [M+H]+.

References

[1] Patent: WO2015/91647, 2015, A1. Location in patent: Page/Page column 42

bromchlorenone(5579-85-1)Related Product Information

• Benzoxazole
• 3-Bromoanisole
• 2-AMINO-5-BROMOPHENOL
• 2-Bromochlorobenzene
• bromchlorenone
• 2-Benzoxazolinone, 6-bromo-5-chloro-3-(3-chloropropyl)-
• 3-BROMO-4-CHLOROPHENOL
• 4-BROMO-3-CHLOROANILINE
• 2-Benzoxazolinone
• 3-BROMO-4-CHLOROANISOLE
• 6-BROMO-BENZOXAZOLINONE
• 3-Bromophenol
• Chlorzoxazone
• 4-BROMO-2-METHOXY-PHENYLAMINE