3-Bromophenol Chemical Properties

Melting point:

30 °C

Boiling point:

236 °C(lit.)

Density 

1,63 g/cm³

refractive index 

1.595-1.599

RTECS 

SJ7874900

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

alcohol: soluble

form 

Liquid

pka

9.03(at 25℃)

color 

Clear colorless, yellow or brownish

Specific Gravity

1.610 (20/4℃)

Water Solubility 

insoluble

Sensitive 

Light Sensitive

Merck 

14,1428

BRN 

1853950

CAS DataBase Reference

591-20-8(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 3-bromo-(591-20-8)

EPA Substance Registry System

Phenol, 3-bromo- (591-20-8)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22-20/21/22

Safety Statements 

26-36/39-36/37/39-36

RIDADR 

2811

WGK Germany 

3

F 

8-10-23

Hazard Note 

Harmful/Irritant

TSCA 

T

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29081000

Hazardous Substances Data

591-20-8(Hazardous Substances Data)

MSDS

• Language:English Provider:3-Bromophenol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Bromophenol Usage And Synthesis

Chemical Properties

Low-Melting Pale Yellow Semi-Solid. soluble in ether, ethanol and chloroform.

Uses

3-Bromophenol acts as an enzyme inhibitor. It is used in the preparation of 3-bromophenyl ester by reaction with benzoyl chloride in presence of triethylamine as a catalyst. It plays an important role as an intermediate in the manufacture of pharmaceuticals, agrochemicals and dyestuff and in organic synthesis.

Application

3-Bromophenol is an intermediate of organic synthesis and can be used to synthesize 3-bromoanisole; it is also the raw material for the synthesis of anticancer analgesic tramadol, triarylmethane thiophene anti-tuberculosis drugs and 4-aryl piperidine antipruritic drugs.

Preparation

3-bromophenol is synthesized by diazotization and bromination of 3-aminophenol. Dissolve 3-aminophenol in sulfuric acid, cool to below 10°C, and add aqueous sodium nitrite dropwise. After the diazotization reaction, the filtrate is filtered and hydrolyzed with cuprous bromide. Then distillation, collect the evaporated liquid with table salt and filter, the filtrate is extracted with ether, the extract is dried, distilled to recover the ether, and then distilled 3-bromophenol.

3-Bromophenol(591-20-8)Related Product Information

• 4-Bromo-2-chlorophenol
• 4-Aminophenol
• 2,6-Dibromophenol
• 3-Bromotoluene
• 2-Phenylphenol
• 3-Aminophenol
• Pentabromophenol
• TETRABROMOCATECHOL
• Decabromodiphenyl oxide
• 3-Bromoanisole
• 4-Bromo-1,2-(methylenedioxy)benzene
• 6-Bromoveratraldehyde
• 3,4,5,6-TETRABROMO-O-CRESOL
• 2,4-BROMOPHENOL
• Bromophenol Blue
• 3-Bromonitrobenzene
• 1-Bromo-2,5-dimethoxybenzene
• 4-Nitrophenol