clofexamide Chemical Properties

Melting point:

45 °C

Boiling point:

124.5°C (rough estimate)

Density 

1.1742 (rough estimate)

refractive index 

1.5200 (estimate)

pka

14.19±0.46(Predicted)

Safety Information

Toxicity

LD50 oral in rat: 1040mg/kg

clofexamide Usage And Synthesis

Originator

Clofexamide ,CNRS

Manufacturing Process

In 1 L of water there is dissolved 116.0 g (1 mole) of N,Ndiethylethylenediamine and, under vigorous stirring at a temperature maintained below 50°C, there is added 205.0 g (1 mole) of the chloride of pchlorphenoxyacetic acid. The solution becomes rapidly homogeneous; the formation of the basic amide hydrochloride is rapidly completed by further stirring the reaction mixture for 2 h at about 20°C. Then an excess of soda lye is added and the basic amide formed is extracted by ether. The ethereal solution is dried on anhydrous sodium sulfate and ether is distilled after that the residue is dried. So 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl) acetamide is obtained.

Therapeutic Function

Antidepressant, Analgesic, Antiinflammatory, Local anesthetic

clofexamide (1223-36-5)Related Product Information

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• clofexamide
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