amiphenazole Chemical Properties

Melting point:

163.5°C (rough estimate)

Boiling point:

413.3±25.0 °C(Predicted)

Density 

1.1906 (rough estimate)

refractive index 

1.5300 (estimate)

pka

5.12±0.10(Predicted)

amiphenazole Usage And Synthesis

Originator

Aamphisol,RJR

Definition

ChEBI: Amiphenazole is a member of thiazoles.

Manufacturing Process

Thiourea reacted with α-bromophenylacetonitrile and as a result of this reaction 2-(cyanophenylmethyl)isothiourea was obtained.
By cyclisation of the 2-(cyanophenylmethyl)isothiourea 2,4-diamino-5- phenylthiazole (amiphenazol) was produced.

Therapeutic Function

Respiratory stimulant, Barbiturate antagonist, Morphine antagonist

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 4517, 1951 DOI: 10.1021/ja01154a005

Purification Methods

The thiazole crystallises from aqueous EtOH or water. Store it in the dark under N2. The hydrochloride has m 273-274o(dec) (from MeOH/EtOAc), and the picrate has m 189-191o(dec) (from H2O). [Davies et al. J Chem Soc 3491 1950, Dodson & Turner J Am Chem Soc 73 4517 1951, Beilstein 27 III/IV 5139.]

amiphenazole(490-55-1)Related Product Information

• Omeprazole
• 2-AMINO-5-METHYLTHIAZOLE
• 5-phenylthiazol-2-amine
• 2,4-DIAMINO-5-PHENYLTHIAZOLE MONOHYDROBROMIDE
• amiphenazole
• thiazol-4-amine