4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]- Basic information
- Product Name:
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-
- Synonyms:
-
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (2S,5R,6R)- (9CI)
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2a,5a,6b)]-
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, hydroxymethyl ester pivalate (ester), monohydrochloride, (+)- (8CI)
- Selexid
- PIVMECILLINUMHYDROCHLORIDE
- Amidinocillin Pivoxil
- Melysin
- CAS:
- 32887-03-9
- MF:
- C21H34ClN3O5S
- MW:
- 476.02976
- EINECS:
- 251-278-7
- Mol File:
- 32887-03-9.mol
More
Less
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]- Chemical Properties
- Melting point:
- 172-173°
- alpha
- D20 +219° (c = 1 in 0.1N HCl)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Freely soluble in water, in anhydrous ethanol and in methanol, slightly soluble in acetone.
- form
- Solid
- color
- White to off-white
- CAS DataBase Reference
- 32887-03-9
More
Less
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]- Usage And Synthesis
Chemical Properties
White or almost white, crystalline powder.
Uses
Pivmecillinam is an orally active prodrug of Amdinocillin (A576300), an broad spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2.
in vivo
Pivmecillinam (0.5 and 1 mg per mouse, subcutaneous injection, three times daily for four days) can effectively inhibit urinary tract infections caused by multidrug-resistant E. coli in a mouse model of urinary tract infection induced by catheter injection of E. coli[4].
| Animal Model: | Mouse urinary tract infection (UTI) model? (OF1 female mice were inoculated with approximately 109 CFU/mL E. coli bacterial suspension through a catheter)[4] |
| Dosage: | 0.5 and 1 mg/mouse |
| Administration: | Subcutaneous injection? (s.c.), three times daily for 4 days |
| Result: | Significantly reduced the number of E. coli strains in the urine, bladder, and kidneys, especially in the urine. |
IC 50
β-lactam
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-Supplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532
- jkinfo@jkchemical.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
ChemStrong Scientific Co.,Ltd
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com
More
Less
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-(32887-03-9)Related Product Information
- NORFLUOXETINE HYDROCHLORIDE
- N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide
- Bispyridoxine
- (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)
- 3-Dechloro-3-broMo Trazodone Hydrochloride
- Thioridazine-d3 Hydrochloride
- PIVMECILLINAM
- D-VALINE METHYL ESTER HYDROCHLORIDE
- 4-METHOXY-2-METHYL-2-BUTANETHIOL
- D-Cysteine hydrochloride
- Mecillinam
- N-ALPHA-METHYL-D-VALINE HYDROCHLORIDE
- D-PENCILLAMINE METHYL ESTER HYDROCHLORIDE
- 1,4-Thiazepane hydrochloride
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-
- D(-)PENICILLAMINE HYDROCHLORIDE
- pivalyloxymethyl butyrate
- METHYL 2-AMINO-3-MERCAPTOPROPANOATE HYDROCHLORIDE