SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA Chemical Properties

storage temp. 

−20°C

solubility 

0.1 M acetic acid: soluble1mg/mL

form 

powder

color 

white

BRN 

5153552

Safety Information

WGK Germany 

3

SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA Usage And Synthesis

Uses

Substance P acetate salt hydrate has been:

• used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
• administered in central nucleus (ACE) in rat to study its positive reinforcing effects
• used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

General Description

Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

Biochem/physiol Actions

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA(137348-11-9)Related Product Information

• ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O
• ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-GLY-LYS-ARG
• SUBSTANCE P, TAMRA-LABELED
• FAM-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
• SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA