2-BENZIMIDAZOLEPROPIONIC ACID
2-BENZIMIDAZOLEPROPIONIC ACID Basic information
- Product Name:
- 2-BENZIMIDAZOLEPROPIONIC ACID
- Synonyms:
-
- 2-(2-carboxyethyl)benzimidazole
- (2-benzimidazolyl)propionicacid
- 1h-benzimidazole-2-propanoicacid
- 2-(2-benzimidazolyl)-propionicaci
- 1H-Benzimidazole-2-propionic acid
- 3-(1H-Benzoimidazole-2-yl)propanoic acid
- 3-(1H-Benzoimidazole-2-yl)propionic acid
- 1H-BenziMidazol-2-propionic acid
- CAS:
- 23249-97-0
- MF:
- C10H10N2O2
- MW:
- 190.2
- Product Categories:
-
- Benzimidazoles
- Building Blocks
- Heterocyclic Building Blocks
- BENZIMIDAZOLE
- Building Blocks
- Chemical Synthesis
- Heterocyclic Building Blocks
- ESTIMULOCEL
- Mol File:
- 23249-97-0.mol
2-BENZIMIDAZOLEPROPIONIC ACID Chemical Properties
- Melting point:
- 229-231 °C (dec.)(lit.)
- Boiling point:
- 497.9±28.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 30 mg/mL (157.73 mM)
- form
- Solid
- pka
- 3.98±0.10(Predicted)
- color
- White to off-white
- Merck
- 13,7851
- CAS DataBase Reference
- 23249-97-0(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- RTECS
- UE7480000
- HazardClass
- IRRITANT
- HS Code
- 29332990
2-BENZIMIDAZOLEPROPIONIC ACID Usage And Synthesis
Uses
immune stimulant
Uses
2-Benzimidazolepropionic acid is suitable reagent for use in the method of generation of monoclonal antibodies against very small drug hapten, 5-benzimidazolecarboxylic acid by in vivo immunisation method and an in vitro immunisation procedure. It may be used in the synthesis of cytidine derivatives.
Definition
ChEBI: Procodazole is a member of benzimidazoles.
General Description
2-Benzimidazolepropionic acid is a 2-(4-thiazolyl)benzimidazole analog. 2-Benzimidazolepropionic acid is a 2-substituted benzimidazole ligand and its dissociation constant has been evaluated. 2-Benzimidazolepropionic acid is reported to possess active antimarial activity.
in vivo
Procodazole (50 mg per dog, p.o., once daily for 28 days) can significantly reduce the parasite burden in Beagles infected with Toxocara canis and enhance their resistance to Toxocara canisinfection[1].
| Animal Model: | Three-month-old Beagle puppies infected with 3000 embryonated Toxocara canis eggs[2] |
| Dosage: | 50 mg per dog |
| Administration: | Oral gavage (p.o.), once daily for 28 days |
| Result: | Reduced the number of worms significantly in the treated group compared to the untreated group, with a 63.8% reduction in worm burden. |
IC 50
CA Ⅸ: 8.35 μM (IC50)
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2-BENZIMIDAZOLEPROPIONIC ACID(23249-97-0)Related Product Information
- 2-BENZIMIDAZOLEPROPIONIC ACID
- methyl 1-methyl-1H-indole-2-carboxylate
- 1-Methylindole-2-carboxylic acid
- TERT-BUTYL 1-METHYL-4-NITRO-1H-PYRROLE-2-CARBOXYLATE
- METHYL 1-METHYLPYRROLE-2-CARBOXYLATE
- 4-(2,4-DICHLOROBENZOYL)-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
- ETHYL 4-CHLORO-5-METHYL-7-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLATE
- METHYL 4-(2,4-DICHLOROBENZOYL)-1-METHYL-1H-PYRROLE-2-CARBOXYLATE
- 4-ACETYL-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
- ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-PYRROLE-2-CARBOXYLATE
- ETHYL 1-(4-CHLOROBENZYL)-3-(1H-PYRROL-1-YL)-1H-INDOLE-2-CARBOXYLATE
- 1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID
- METHYL 4-ACETYL-1-METHYL-1H-PYRROLE-2-CARBOXYLATE
- SPECS AE-508/36399029
- ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-(1H-PYRROL-1-YL)-1H-INDOLE-2-CARBOXYLATE
- 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-PYRROLE-2-CARBOXYLIC ACID
- RARECHEM AL BF 0409
- ETHYL 1-(2,4-DICHLOROBENZYL)-3-((2,4-DICHLOROBENZYL)[3-(TRIFLUOROMETHYL)BENZOYL]AMINO)-1H-INDOLE-2-CARBOXYLATE