1-Methylindole-2-carboxylic acid Chemical Properties

Melting point:

212-213 °C (dec.) (lit.)

Boiling point:

389.0±15.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Crystalline Powder

pka

4.19±0.30(Predicted)

color 

Beige

CAS DataBase Reference

16136-58-6(CAS DataBase Reference)

NIST Chemistry Reference

1-Methylindole-2-carboxylic acid(16136-58-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

RTECS 

NL6012400

HazardClass 

IRRITANT

HS Code 

29339980

MSDS

• Language:English Provider:SigmaAldrich

1-Methylindole-2-carboxylic acid Usage And Synthesis

Chemical Properties

Beige crystalline powder

Uses

• ;Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors1• ;Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions2• ;Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes3• ;Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation4• ;Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications ag

Uses

• Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
• Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions
• Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes
• Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation
• Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis
• Reactant for preparation of anthranilic acid mimics as bacterial translation inhibitors

General Description

1-Methylindole-2-carboxylic acid reacts with thionyl chloride to yield sulfinyl chlorides.

1-Methylindole-2-carboxylic acid(16136-58-6)Related Product Information

• Phthalic acid
• Methyl formate
• Benzyl benzoate
• Thiophanate-methyl
• Methyl salicylate
• Benzoic acid
• Bensulfuron methyl
• 4-Methyl-2-pentanol
• 2-Methylindole
• Calcium formate
• Ethyl 2-(Chlorosulfonyl)acetate
• Indole
• Ethyl formate
• Folic acid
• Indole-2-carboxylic acid
• Retinoic acid
• Citric acid
• 1-Methylindole