Basic information Safety Supplier Related

Indole-2-carboxylic acid

Basic information Safety Supplier Related

Indole-2-carboxylic acid Basic information

Product Name:
Indole-2-carboxylic acid
Synonyms:
  • NSC 16598
  • Indole-2-carboxylic
  • Indole-2-earboxylic acid ethylester
  • INDOLE-2-CARBOXYLIC ACID(I2CA)
  • Indole-2-carboxylic acid,99%
  • Indole-2-carboxylic acid   Indole-2-carboxylic acid
  • Indole-2-carboxylacid
  • 1H-Indole-2-carboxylic acid 98%
CAS:
1477-50-5
MF:
C9H7NO2
MW:
161.16
EINECS:
216-030-4
Product Categories:
  • Simple Indoles
  • Amino Acids & Derivatives
  • Carboxylic Acids
  • Indole Derivatives
  • Carboxylic Acids
  • Pyrroles & Indoles
  • Indole/indoline/oxindole
  • indole derivative
  • Indole and Indoline
  • Pyrroles & Indoles
  • Indole
  • Organic acids
  • Amino Acids 13C, 2H, 15N
  • Indoles
  • Indoles and derivatives
  • Bioactive Small Molecules
  • Building Blocks
  • C7 to C9
  • Cell Biology
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • I
  • Heterocycle-Indole series
  • commercial
  • bc0001
  • 1477-50-5
Mol File:
1477-50-5.mol
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Indole-2-carboxylic acid Chemical Properties

Melting point:
202-206 °C(lit.)
Boiling point:
287.44°C (rough estimate)
Density 
1.2480 (rough estimate)
refractive index 
1.5050 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in clear yellow solution 5% in ethanol, dimethyl sulfoxide and methanol.
pka
4.44±0.30(Predicted)
form 
Crystalline Powder or Crystals
color 
Off-white to yellow to brown
BRN 
124132
CAS DataBase Reference
1477-50-5(CAS DataBase Reference)
NIST Chemistry Reference
Indole-2-carboxylic acid(1477-50-5)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-21/22
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
NK7882812
HazardClass 
IRRITANT
HS Code 
29339990

MSDS

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Indole-2-carboxylic acid Usage And Synthesis

Chemical Properties

Yellow Crystalline Powder

Uses

• ;Reactant for total synthesis of (±)-dibromophakellin and analogs1• ;Reactant for synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine2• ;Reactant for stereoselective preparation of renieramycin G analogs3• ;Reactant for preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization4• ;Reactant for Pd-catalyzed cyclization5• ;Reactant for preparation of N,N′-(pentane)diylbis[indolecarboxamide] and N,N′-[phenylenebis(

Uses

Reactant for total synthesis of (±)-dibromophakellin and analogs, synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine, stereo selective preparation of renieramycin G analogs, preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization, Pd-catalyzed cyclization and N,N?-(pentane)diylbis[indolecarboxamide] and N,N?-[phenylenebis(methylene)]bis[indolecarboxamide] derivatives.

Definition

ChEBI: Indole-2-carboxylic acid is an indolyl carboxylic acid.

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 7961, 1992 DOI: 10.1016/S0040-4039(00)74789-7

Indole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Indole-2-carboxylic acidSupplier

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