Ethyl indole-2-carboxylate Chemical Properties

Melting point:

122-125 °C (lit.)

Boiling point:

324.47°C (rough estimate)

Density 

1.1596 (rough estimate)

refractive index 

1.5012 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

15.01±0.30(Predicted)

form 

Crystals or Crystalline Powder

color 

White to yellow

BRN 

146395

InChI

InChI=1S/C11H11NO2/c1-2-14-11(13)10-7-8-5-3-4-6-9(8)12-10/h3-7,12H,2H2,1H3

InChIKey

QQXQAEWRSVZPJM-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2)C=C1C(OCC)=O

CAS DataBase Reference

3770-50-1(CAS DataBase Reference)

NIST Chemistry Reference

1H-indole-2-carboxylic acid, ethyl ester(3770-50-1)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

Hazard Note 

Keep Cold

HazardClass 

IRRITANT

HS Code 

29339990

MSDS

• Language:English Provider:Ethyl indole-2-carboxylate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Ethyl indole-2-carboxylate Usage And Synthesis

Chemical Properties

white to yellow crystals or crystalline powder

Uses

Reactant for preparation of:CRTH2 receptor antagonists;Indoleamine 2,3-dioxygenase (IDO) inhibitors;Cannabinoid CB1 receptor antagonists; Inhibitors of Human Reticulocyte 15-Lipoxygenase-1;N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents;A antiproliferative agent against human leukemia K562 cells;Inhibitors of p38 MAP kinase; Acetolactate synthase inhibitors.

Uses

2-Ethoxycarbonylindole is a building block that has been used as a reactant for the preparation of pyridazinoindole derivatives that have antimicrobial activities.

Preparation

Indole-2-carb-oxy-lic acid (0.50 g, 3.1 mmol) was dissolved in SOCl2 (19 ml) at 0°C. After stirring for 1 h, the solution was rotary evaporated, and the resulting oil was added to absolute ethanol (17 ml) at room temperature. After stirring overnight, the solution was vacuum filtered to yield ethyl 1H-indole-2-carboxyl-ate as a beige solid, which was recrystallized from methanol to yield 0.54 g (2.9 mmol, 93%) of the product[1].

References

[1] Will E. Lynch , Clifford W. Padgett, Christine R. Whitlock . “Ethyl 1H-indole-2-carboxyl-ate.” IUCrData 5 (2020): Article x201205.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 39, p. 1152, 1991 DOI: 10.1248/cpb.39.1152

structure and hydrogen bonding

Lynch et al. report the crystal structure of ethyl 1H-indole-2-carboxyl-ate, which forms a hydrogen-bonded dimer. The hydrogen bonding occurs between N atoms of the indole ring and the keto oxygen atoms with an R(10) synthon. The hydrogen bond between N1 and O2i is characterized by an N…O separation of 2.877 Å;, and the ring motifs are placed on inversion centres in the space group P21/c. The crystal structure exhibits a classic herringbone pattern, with the blocks of hydrogen-bonded dimers and the zigzag running along the b-axis direction. The mol-ecule is nearly planar, with a r.m.s.d. of 0.028 Å for the non-hydrogen atoms. No other short contacts or π–π inter-actions are observed in the crystal[1].

Ethyl indole-2-carboxylate(3770-50-1)Related Product Information

• Indometacin
• Indole-3-acetic acid
• Indole-3-butyric acid
• Indole-2-carboxylic acid
• Tris(trimethylsilyl)phosphate
• Ethyl acetate
• Ethyl acrylate
• Indole
• RESMETHRIN
• Ethylparaben
• 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester
• Ethanol
• ETHYL INDOLE-5-CARBOXYLATE
• ETHYL INDOLE-3-CARBOXYLATE
• Indole-5-carboxylic acid
• Methyl indole-5-carboxylate
• Indole-4-carboxylic acid
• 3-Indolepropionic acid