Pipethanate Chemical Properties

Melting point:

168-169 °C

Boiling point:

444.1±24.0 °C(Predicted)

Density 

1.155±0.06 g/cm3(Predicted)

pka

11.34±0.29(Predicted)

Pipethanate Usage And Synthesis

Originator

Panpurol ,Nippon Shinyaku, Japan

Definition

ChEBI: Pipethanate is a diarylmethane.

Manufacturing Process

Pipethanate hydrochloride is dissolved in water and the solution is made alkaline by adding 10% sodium hydroxide solution. The crystals that are separated are filtered off and recrystallized from dilute ethanol. The monohydrate thereby obtained is dehydrated at 100°C under reduced pressure for 20 minutes. The products that are now in the form of a syrup due to loss of water of crystallization are further dehydrated for 2 days in a desiccator over phosphorus pentoxide whereupon the anhydrous pipethanate is obtained.
3.8 g of the anhydrous pipethanate prepared by the method described is dissolved in 15 cc of acetone, 18 g of purified ethyl bromide is added, and the mixture heated for 8 hours in a sealed tube at 100°C to 110°C. After cooling the crystals are separated and isolated by filtration. They are then washed with acetone to give 5.2 g (95.6%) of pipethanate ethylbromide with a decomposition point of 218°C to 220°C. The crystals are almost pure.

Therapeutic Function

Anticholinergic, Antiulcer

Pipethanate(4546-39-8)Related Product Information

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• (R)-(-)-3-QUINUCLIDINYL BENZILATE
• R(-)-QNB METHIODIDE
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• Pipethanate ethylbromide
• 3-Quinuclidinyl 9-hydroxyxanthene-9-carboxylate
• N-METHYL L-QNB, [N-METHYL-3H]-
• Clidinium bromide
• 3-Quinuclidinyl benzilate
• L-QUINUCLIDINYL BENZILATE, [BENZYLIC-4,4'-3H(N)]
• Pipethanate