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Levofloxacin heMihydrate

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Levofloxacin heMihydrate Basic information

Product Name:
Levofloxacin heMihydrate
Synonyms:
  • Levofloacin Impurity 16
  • levofloxacin hydrate
  • LEVOFLOXACIN HCL
  • (s)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1)
  • LEVOFLOXACINH HYDROCHLORIDE
  • (S)-(-)-Ofloxacine
  • Levofloxacine
  • (-)-(s)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride
CAS:
138199-71-0
MF:
C18H22FN3O5
MW:
379.39
EINECS:
604-067-2
Product Categories:
  • TEQUIN
  • Chiral Reagents
  • Antibiotic Explorer
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
138199-71-0.mol
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Levofloxacin heMihydrate Chemical Properties

Melting point:
214-216°C
storage temp. 
Sealed in dry,2-8°C
solubility 
Aqueous Base (Slightly), DMSO (Sparingly), Methanol (Slightly)
form 
Solid
color 
Pale Yellow to Light Yellow
CAS DataBase Reference
138199-71-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
24/25-61-60
WGK Germany 
3
HS Code 
2934990002
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Levofloxacin heMihydrate Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

antibacterial

Uses

Levofloxacin Hemihydrate is a S-(-) form of Ofloxacin (O245750), an antibiotic used against gram-negative organisms.

Uses

Levofloxacin heMihydrate is an antibiotic used against gram-negative organisms.

brand name

Iquix (Sanofi Winthrop); Levaquin (Ortho-McNeil); Quixin (Sanofi Winthrop).

in vivo

Levofloxacin (10.7 mg/kg; i.p., once daily for 10 days or 3 weeks) time-dependently induces toxic effects on liver and heart in albino mice[4].

Animal Model:Matured male Albino mice[4]
Dosage:10.7 mg/kg
Administration:Intraperitoneal injection; 10.7 mg/kg, once daily for 10 days or 3 weeks
Result:Induced severe congestion of blood vessels in the portal area, central veins with inflammatory cells infiltration, necrosis with pyknosis of cardiac muscle nuclei and apoptosis, degeneration and necrosis of hepatocytes.

IC 50

TOPO IV

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