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Quinolones

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Development of synthetic quinolone antibacterial agents has experienced three generations. The typical representative of the first generation quinolone is the nalidixic acid developed in 1962. It is effective in the treatment of Gram-negative bacteria such as Escherichia coli but not effective in the treatment in Pseudomonas aeruginosa and gram-positive bacteria with poor absorption capability and low biological availability. It is easy to cause bacteria drug resistance and thus had been eliminated. Typical representative of the secondary generation of quinolones include oxolinic acid and pipemidic acid developed in 1970s. In 1979, our country had applied pipemidic acid to the treatment of infections caused by Gram-negative bacteria and had achieved excellent efficacy. It therapeutic efficacy on Pseudomonas aeruginosa infection is superior to nalidixic acid and carbenicillin, but not as good as gentamicin. The disadvantage is that it has a poor efficacy in the treatment of gram-positive bacteria with low blood levels as well as certain central nervous system toxicity.

In the late 1970s, the development of cephalosporins had reached its peak. However, the price is so high that general patient can hardly afford it. The development of the third generation quinolone-synthetic fluoroquinolone antibiotic had given the world the feeling of “mountains multiply and streams double back no doubt, there is a way out". Fluoroquinolone antibiotic refers to the novel type of quinolone antibacterial drugs with the six position of the synthetic quinazoline ring being introduced into a fluorine atom. They not only have a 4-64 fold stronger efficacy against gram-negative bacteria than the first and second generation quinolones, but also have an 8 to 64 fold stronger effect than the first and second generation quinolones in the treatment of gram-positive bacteria. Moreover, they have excellent oral absorption property and rarely cause drug resistance. Furthermore, as a kind of synthetic chemicals, it is relatively more inexpensive than general antibiotics (especially third generation cephalosporins).

The DNA of bacterial cells exists in the form of double-stranded helix with the formation of double helix relying on the action of DNA gyrase. The mechanism of action of quinolones is through the inhibition of DNA gyrase, causing chromosome damage, resulting in the failure of the division and reproduction of the cells. Because of its unique mechanism of action, which is free of the impact from the plasmid conducting drug resistance, it has no cross-resistance with many kinds of antibacterial drugs.

The advantage of fluoroquinolone antibiotics are as follows:
1. It has broad antimicrobial spectrum and strong antibacterial activity with some of them (such as ofloxacin) having their effects comparable with third-generation cephalosporins. It also has effect against Gram-positive bacteria Staphylococcus aureus and refractory methicillin-resistant Staphylococcus aureus (MRSA); in terms of its antibacterial effect against gram-negative bacteria, it has spread to Pseudomonas aeruginosa, Haemophilus influenzae, and penicillin enzyme-producing Neisseria gonorrhoeae; some kinds of novel fluoroquinolone antibiotics are even effective in the treatment of mycoplasma and chlamydia.
2. It has excellent oral absorption property with wide tissue distribution. Usually fluoro quinolone administrated orally need 1 to 2 hours to reach the concentration peak in blood. It has a low plasma protein binding rate at about 10% to 40%. After the drug administration, it can be widely distributed in liver, kidney, skin and lungs and other tissues.
3. It has wide range of treatment with certain therapeutic effect on intestinal, urinary tract, biliary tract, respiratory tract infections, prostatitis, osteomyelitis, etc. It is widely used in the treatment of infections of various subjects.
4. Low incidence of drug resistance. Ofloxacin, used in Germany, can still inhibit over 96.8% of Gram-negative bacteria and 93.3% of gram-positive bacteria after eight years; ciprofloxacin used in the UK has 91% of Pseudomonas aeruginosa and 95% of Staphylococcus be sensitive to it; However, there is research in our country indicated that the resistance against fluoroquinolone for Pseudomonas aeruginosa has risen in recent years, from 4.4% to 10%.

Characteristics of fluoroquinolone antibiotics are as follows.
1. Its antibacterial effect, in general, is poorer against gram-positive bacteria than gram-negative bacteria.
2. The related adverse effects include gastrointestinal symptoms, usually doesn’t need stopping; for central nervous system symptoms, such as anxiety, nervousness, insomnia and headaches are more common for ciprofloxacin; rash may also occur; the incidence of liver and kidney dysfunction is generally 0.5% to 1.0%.
3. Long-term puppy magnetic resonance imaging (MRI) and ultrasound studies have shown that there is loose phenomenon occurring on the intermediate layer of bone and joint cartilage matrix. However, this phenomenon hasn’t been observed in hundreds of cases of human. Still for safety purpose, this class of drugs is not recommended to be long-term administrated to lactating woman and children upon bone development in large dose. Because this product inhibit the replication of DNA, so pregnant women should also administrate it with caution.
4. Individual kinds of fluoroquinolones (such as lomefloxacin, enoxacin and sparfloxacin), when being subject to long-term administration to elderly outdoor-working farmers in large dose, can cause phototoxic reactions in a few cases.

There are several conditions where drug interactions can happen:
1. administration together with milk, cheese and calcium, magnesium, iron, aluminum and other drugs will affect the antibacterial effect; it is generally recommended to be administrated upon an empty stomach; if administrated after meals, the peak time of drug in the blood will be postponed for 1 to 2 hours, but the total amount of the absorption will not be affected; acidic urine can further facilitate its excretion while precipitation can happen in alkaline urine.
2. Interaction with theophylline and other xanthine drugs can be divided into three categories: when administrated together with enoxacin, the plasma concentration of theophylline can be increased by two fold; administration together with tosufloxacin and ciprofloxain can cause 20% increase of the blood concentration of theophylline; administration together with lomefloxacin and norfloxacin has no effect on plasma concentrations of theophylline.
3. Administration together with non-steroidal anti-inflammatory drugs fenbufen can promote the binding between fenbufen and γ- aminobutyric acid (GABA) receptors to induce epileptic seizures, so patients with a history of epilepsy should administrate with caution.
4. Administration together with other antimicrobial agents should also be cautious. For example, combination with vancomycin can cause increase in renal toxicity; combination with doxorubicin, furadantin can cause decreased kidney function (ciprofloxacin); combination with chloramphenicol, doxycycline, clindamycin and macrolide antibiotic can even cause decrease of its antibacterial effect, and can also prone to lead to adverse reactions of hematopoietic system and the nervous system.

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Structure:
Chemical Name:
Moxifloxacin
CAS:
151096-09-2
MF:
C21H24FN3O4
Structure:
Chemical Name:
Balofloxacin
CAS:
127294-70-6
MF:
C20H24FN3O4
Structure:
Chemical Name:
Sarafloxacin hydrochloride
CAS:
91296-87-6
MF:
C20H18ClF2N3O3
Structure:
Chemical Name:
Norfloxacin
CAS:
70458-96-7
MF:
C16H18FN3O3
Structure:
Chemical Name:
Gatifloxacin
CAS:
112811-59-3
MF:
C19H22FN3O4
Structure:
Chemical Name:
Pazufloxacin
CAS:
127045-41-4
MF:
C16H15FN2O4
Structure:
Chemical Name:
Moxifloxacin hydrochloride
CAS:
186826-86-8
MF:
C21H25ClFN3O4
Structure:
Chemical Name:
Nadifloxacin
CAS:
124858-35-1
MF:
C19H21FN2O4
Structure:
Chemical Name:
Gemifioxacin
CAS:
175463-14-6
MF:
C18H20FN5O4
Structure:
Chemical Name:
Difloxacin
CAS:
98106-17-3
MF:
C21H19F2N3O3
Structure:
Chemical Name:
Prulifloxacin
CAS:
123447-62-1
MF:
C21H20FN3O6S
Structure:
Chemical Name:
Enrofloxacin hydrochloride
CAS:
112732-17-9
MF:
C19H23ClFN3O3
Structure:
Chemical Name:
Gatifloxacin sesquihydrate
CAS:
180200-66-2
MF:
C19H24FN3O5
Structure:
Chemical Name:
Marbofloxacin
CAS:
115550-35-1
MF:
C17H19FN4O4
Structure:
Chemical Name:
Pazufloxacin mesilate
CAS:
163680-77-1
MF:
C17H19FN2O7S
Structure:
Chemical Name:
Sarafloxacin
CAS:
98105-99-8
MF:
C20H17F2N3O3
Structure:
Chemical Name:
1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID
CAS:
149676-40-4
MF:
C18H28FN3O8S
Structure:
Chemical Name:
Levofloxacin carboxylic acid
CAS:
100986-89-8
MF:
C13H9F2NO4
Structure:
Chemical Name:
SITAFLOXACIN
CAS:
163253-35-8
MF:
C19H18ClF2N3O3.H2O
Structure:
Chemical Name:
Tosufloxacin tosylate
CAS:
115964-29-9
MF:
C26H23F3N4O6S
Structure:
Chemical Name:
Nalidixic acid
CAS:
389-08-2
MF:
C12H12N2O3
Structure:
Chemical Name:
Fleroxacin
CAS:
79660-72-3
MF:
C17H18F3N3O3
Structure:
Chemical Name:
TROVAFLOXACIN
CAS:
147059-72-1
MF:
C20H15F3N4O3
Structure:
Chemical Name:
Enoxacin
CAS:
74011-58-8
MF:
C15H17FN4O3
Structure:
Chemical Name:
Orbifloxacin
CAS:
113617-63-3
MF:
C19H20F3N3O3
Structure:
Chemical Name:
CINOXACIN
CAS:
28657-80-9
MF:
C12H10N2O5
Structure:
Chemical Name:
Levofloxacin hydrochloride
CAS:
100986-85-4
MF:
C18H20FN3O4
Structure:
Chemical Name:
TEMAFLOXACIN
CAS:
108319-06-8
MF:
C21H18F3N3O3
Structure:
Chemical Name:
Sparfloxacin
CAS:
111542-93-9
MF:
C19H22F2N4O3
Structure:
Chemical Name:
Grepafloxacin
CAS:
119914-60-2
MF:
C19H22FN3O3
Structure:
Chemical Name:
TOSUFLOXACIN TOSILATE
CAS:
100490-36-6
MF:
C19H15F3N4O3
Structure:
Chemical Name:
DANOFLOXACIN
CAS:
112398-08-0
MF:
C19H20FN3O3
Structure:
Chemical Name:
Gemifioxacin mesylate
CAS:
210353-53-0
MF:
C19H24FN5O7S
Structure:
Chemical Name:
Lomefloxacin hydrochloride
CAS:
98079-52-8
MF:
C17H20ClF2N3O3
Structure:
Chemical Name:
Clinafloxacin
CAS:
105956-97-6
MF:
C17H17ClFN3O3
Structure:
Chemical Name:
Besifloxacin hydrochloride
CAS:
405165-61-9
MF:
C19H21ClFN3O3.ClH
Structure:
Chemical Name:
Enoxacin
CAS:
84294-96-2
MF:
C30H40F2N8O9
Structure:
Chemical Name:
Ofloxacin
CAS:
82419-36-1
MF:
C18H20FN3O4
Structure:
Chemical Name:
1-AdaMantanethylaMine
CAS:
13392-28-4
MF:
C12H21N
Structure:
Chemical Name:
Ciprofloxacin lactate
CAS:
97867-33-9
MF:
C20H24FN3O6
Structure:
Chemical Name:
Ciprofloxacin
CAS:
85721-33-1
MF:
C17H18FN3O3
Structure:
Chemical Name:
Sparfloxacin
CAS:
110871-86-8
MF:
C19H22F2N4O3
Structure:
Chemical Name:
Olamufloxacin
CAS:
167887-97-0
MF:
C20H23FN4O3
Structure:
Chemical Name:
Tosufloxacin tosilate
CAS:
107097-79-0
MF:
C26H23F3N4O6S
Structure:
Chemical Name:
Difluoxacin hydrochloride
CAS:
91296-86-5
MF:
C21H20ClF2N3O3
Structure:
Chemical Name:
Sitafloxacin
CAS:
127254-12-0
MF:
C19H18ClF2N3O3
Structure:
Chemical Name:
Gatifloxacin hydrochloride
CAS:
160738-57-8
MF:
C22H28FN3O7
Structure:
Chemical Name:
(R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS:
141388-76-3
MF:
C19H21ClFN3O3
Structure:
Chemical Name:
PRULIFLOXACIN
CAS:
123447-63-2
MF:
C21H20FN3O6S
Structure:
Chemical Name:
Danofloxacin mesylate
CAS:
119478-55-6
MF:
C20H24FN3O6S
Structure:
Chemical Name:
ENOXACIN GLUCONATE
CAS:
104142-71-4
MF:
C15H17FN4O3.C6H12O7.H2O
Structure:
Chemical Name:
OFLOXACIN HYDROCHLORIDE
MF:
C18H21ClFN3O4
Structure:
Chemical Name:
FORMYLCIPROFLOXACIN
CAS:
93594-39-9
MF:
C18H18FN3O4
Structure:
Chemical Name:
Levofloxacin mesylate
CAS:
226578-51-4
MF:
C19H24FN3O7S
Structure:
Chemical Name:
Norfloxacinehydrochloride
CAS:
68077-27-0
MF:
C16H19ClFN3O3
Structure:
Chemical Name:
Garenoxacin
CAS:
194804-75-6
MF:
C23H20F2N2O4
Structure:
Chemical Name:
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-hydroxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
CAS:
721970-36-1
MF:
C20H22FN3O4
Structure:
Chemical Name:
LEVOFLOXACIN ACID ESTER
MF:
C15H13F2NO4
Structure:
Chemical Name:
LEVOFLOXACIN ACID
MF:
C13H9F2NO4
Structure:
Chemical Name:
Desmethyl Levofloxacin
CAS:
117707-40-1
MF:
C17H18FN3O4
Structure:
Chemical Name:
Levofloxacin heMihydrate
CAS:
138199-71-0
MF:
C18H22FN3O5
Structure:
Chemical Name:
RUFLOXACIN
CAS:
101363-10-4
MF:
C17H18FN3O3S
Structure:
Chemical Name:
Ciprofloxacin hydrochloride
CAS:
86483-48-9
MF:
C17H19ClFN3O3
Structure:
Chemical Name:
Ofloxacin hydrochloride
CAS:
118120-51-7
MF:
C18H20FN3O4.HCl
Structure:
Chemical Name:
Finafloxacin Hydrochloride
CAS:
209342-41-6
MF:
C20H20ClFN4O4
Structure:
Chemical Name:
Pefloxacin
CAS:
70458-92-3
MF:
C17H20FN3O3
Structure:
Chemical Name:
Lomefloxacin
CAS:
98079-51-7
MF:
C17H19F2N3O3
Structure:
Chemical Name:
Grepafloxacin hydrochloride
CAS:
161967-81-3
MF:
C19H23ClFN3O3
Structure:
Chemical Name:
Miloxacin
CAS:
37065-29-5
MF:
C12H9NO6
Structure:
Chemical Name:
3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-, (4aS-cis)-
CAS:
151213-15-9
MF:
C20H21F2N3O3
Structure:
Chemical Name:
Clinafloxacin hydrochloride
CAS:
105956-99-8
MF:
C17H18Cl2FN3O3
Structure:
Chemical Name:
1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS:
1029364-75-7
MF:
C22H26FN3O4
Structure:
Chemical Name:
ENROFLOXACIN LACTATE
CAS:
931066-01-2
MF:
C15H16ClN3O2
Structure:
Chemical Name:
Pipemidic acid
CAS:
51940-44-4
MF:
C14H17N5O3
Structure:
Chemical Name:
CIPROFLOXACIN LACTATE
CAS:
857213-31-1
MF:
C20H24FN3O6
Structure:
Chemical Name:
Enrofloxacin Sodium
CAS:
266346-15-0
MF:
C19H21FN3O3.Na
Structure:
Chemical Name:
Pefloxacin mesylate
CAS:
70458-95-6
MF:
C18H24FN3O6S
Structure:
Chemical Name:
MOXIFLOXACIN, HYDROCHLORIDE MONOHYDRATE
CAS:
192927-63-2
MF:
C21H27ClFN3O5
Structure:
Chemical Name:
OXOCIPROFLOXACIN
MF:
C17H16FN3O4
Structure:
Chemical Name:
(S)-(-)-Nadifloxacin
CAS:
154357-42-3
MF:
C19H21FN2O4
Structure:
Chemical Name:
Ciprofloxacin IMpurity A
MF:
C17H18FN3O3
Structure:
Chemical Name:
OFLOXACIN RELATED COMPOUND A (25 MG) ((RS)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-10-(PIPERA-ZIN-1 -YL)-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID)
CAS:
82419-52-1
MF:
C17H18FN3O4
Structure:
Chemical Name:
rosoxacin
CAS:
40034-42-2
MF:
C17H14N2O3
Structure:
Chemical Name:
amifloxacin
CAS:
86393-37-5
MF:
C16H19FN4O3
Structure:
Chemical Name:
Pazufloxacin hydrochloride
CAS:
127046-45-1
MF:
C16H15FN2O4.HCl
Chemical Name:
Gatifloxacin mesylate
Structure:
Chemical Name:
1,2,2,2-tetrafluoroethane
CAS:
29759-38-4
MF:
C16H18FN3O3C6H5NO3
Chemical Name:
SparfloxacinLactate
MF:
C19H22F2N4O3·C3H6O3
Structure:
Chemical Name:
FLEROXACINLACTATE
CAS:
896139-71-2
MF:
C17H18F3N3O3.C3H6O3
Structure:
Chemical Name:
Rufloxacin hydrochloride
CAS:
106017-08-7
MF:
C17H19ClFN3O3S
Chemical Name:
levofloxacin/ofloxacin
Structure:
Chemical Name:
Ciprofloxacin IMpurity E
MF:
C17H18FN3O3
Structure:
Chemical Name:
GATIFLOXACIN MESYLATE
CAS:
316819-28-0
MF:
C19H22FN3O4.CH4O3S
Chemical Name:
Lomefoxacin aspartate
Structure:
Chemical Name:
Cadrofloxacin
CAS:
153808-85-6
MF:
C19H20F3N3O4
Structure:
Chemical Name:
Ciprofloxacin Formamide
MF:
C18H21FN4O4
Chemical Name:
Enrofloxacin nicotinate
Structure:
Chemical Name:
3-Quinolinecarboxylic acid, 1-cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-
CAS:
182868-72-0
MF:
C20H24FN3O4
Structure:
Chemical Name:
CIPROFLOXACIN IMPURITY A
MF:
C17H18FN3O3
Structure:
Chemical Name:
Levofloxacin lactic acid
MF:
C21H24FN3O6