Clinafloxacin
Clinafloxacin Basic information
- Product Name:
- Clinafloxacin
- Synonyms:
-
- 3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-
- 6-Fluoro-8-chloro-1-cyclopropyl-7-(3-aminopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
- 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
- 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
- 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
- CI-960
- PD-127391
- 105956-99-8 (Hydrochloride)
- CAS:
- 105956-97-6
- MF:
- C17H17ClFN3O3
- MW:
- 365.79
- Mol File:
- 105956-97-6.mol
Clinafloxacin Chemical Properties
- Melting point:
- 253-258 C
- Boiling point:
- 592.3±50.0 °C(Predicted)
- Density
- 1.573±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Acetic Acid (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 6.39±0.50(Predicted)
- color
- Pale Beige
- InChI
- InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25)
- InChIKey
- QGPKADBNRMWEQR-UHFFFAOYSA-N
- SMILES
- N1(C2CC2)C2=C(C=C(F)C(N3CCC(N)C3)=C2Cl)C(=O)C(C(O)=O)=C1
- CAS DataBase Reference
- 105956-97-6(CAS DataBase Reference)
- EPA Substance Registry System
- Clinafloxacin (105956-97-6)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-63
- Safety Statements
- 26-36-36/37
- RTECS
- VB1800600
MSDS
- Language:English Provider:7-(3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Clinafloxacin Usage And Synthesis
Uses
Antibacterial.
Uses
Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV.
Definition
ChEBI: 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-3-quinolinecarboxylic acid is a member of quinolines.
in vivo
Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3].
IC 50
Quinolone
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