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6-Aminocaproic acid

Basic information Description References Safety Supplier Related

6-Aminocaproic acid Basic information

Product Name:
6-Aminocaproic acid
Synonyms:
  • 177 J.D
  • 177 J.D.
  • 177j.d.
  • 177jd
  • 6-amino-hexanoicaci
  • Acepramin
  • Acepramine
  • ACS
CAS:
60-32-2
MF:
C6H13NO2
MW:
131.17
EINECS:
200-469-3
Product Categories:
  • omega-Aminocarboxylic Acids
  • omega-Functional Alkanols, Carboxylic Acids, Amines & Halides
  • Organic acids
  • Amino Acids
  • Fibrinogen/Thrombin
  • Pharmaceutical raw materials
  • AMICAR
Mol File:
60-32-2.mol
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6-Aminocaproic acid Chemical Properties

Melting point:
207-209 °C (dec.)(lit.)
Boiling point:
242.49°C (rough estimate)
Density 
1.03 g/mL at 20 °C
vapor pressure 
<0.1 hPa (20 °C)
refractive index 
1.4870 (estimate)
Flash point:
207-209°C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
pka
4.373(at 25℃)
form 
powder
color 
white
Odor
Odorless
PH
7.0-7.5 (50g/l, H2O, 20℃)
Water Solubility 
SOLUBLE
Merck 
14,432
BRN 
906872
InChIKey
SLXKOJJOQWFEFD-UHFFFAOYSA-N
CAS DataBase Reference
60-32-2(CAS DataBase Reference)
NIST Chemistry Reference
Hexanoic acid, 6-amino-(60-32-2)
EPA Substance Registry System
Hexanoic acid, 6-amino- (60-32-2)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
MO6300000
TSCA 
Yes
HS Code 
29224995
Hazardous Substances Data
60-32-2(Hazardous Substances Data)
Toxicity
LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)

MSDS

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6-Aminocaproic acid Usage And Synthesis

Description

6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease.

References

https://pubchem.ncbi.nlm.nih.gov/compound/6-aminohexanoic_acid#section=Pharmacology-and-Biochemistry
https://en.wikipedia.org/wiki/Aminocaproic_acid

Chemical Properties

white crystalline powder

Originator

Epsilon,Roche,W. Germany,1962

Uses

hemostatic

Uses

6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.

Uses

Propylparaben Food preservative

Uses

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Definition

ChEBI: An amino-acid anion that is the conjugate base of 6-aminohexanoic acid.

Manufacturing Process

5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired.

brand name

Amicar (Xanodyne).

Therapeutic Function

Antifibrinolytic

Safety Profile

Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.

Veterinary Drugs and Treatments

Aminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.

6-Aminocaproic acid Preparation Products And Raw materials

Preparation Products

Raw materials

6-Aminocaproic acidSupplier

Chengdu Chuanke Fine Chemicals C.,Ltd. Gold
Tel
+86 (28) 68626087 ;+86-28-85405627
Email
customertwo@ckfc.asia
Products Intro
Product Name:6-AMinohexanoic acid
CAS:60-32-2
Purity:99% Package:25kg
Chemspon Bio-Tech Co., Ltd Gold
Tel
0571-88937695;0571-88937835
Email
sales@chemspon.com;sales@chemspon.com
Products Intro
Product Name:6-Aminocaproic acid
CAS:60-32-2
Purity:99% Package:100g;1kg;10kg;25kg
WUHAN YUANCHENG GONGCHUANG TECHNOLOGY CO.,LTD Gold
Tel
Email
1002757022@qq.com
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Product Name:6-Aminocaproic acid
CAS:60-32-2
Purity:99% Package:25KG/
Shaanxi Pioneer Biotech Co.,Ltd Gold
Tel
029-84385017-8001
Email
sales5@pioneerbiotech.com
Products Intro
Product Name:6-Aminocaproicacid
CAS:60-32-2
Purity:0.99 Package:1kg;25kg;100kg
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro
Product Name:6-Aminohexanoic acid, 99%
CAS:60-32-2
Purity:99% Package:100G;25g;500G