1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID Chemical Properties

Melting point:

271°C

Boiling point:

529℃

Flash point:

>110°(230°F)

storage temp. 

Inert atmosphere,2-8°C

solubility 

H2O: soluble50mg/mL

form 

powder

Water Solubility 

Freely soluble in water

Sensitive 

Light Sensitive

CAS DataBase Reference

149676-40-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

WGK Germany 

3

RTECS 

VB2002200

HS Code 

29335990

1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White powder

Uses

antifungal, calmodulin antagonist

Uses

Pefloxacin Mesylate Dihydrate is an analog of norfloxacin that inhibits topoisomerase.

Biological Activity

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID(149676-40-4)Related Product Information

• Pefloxacin
• Pefloxacin mesylate
• Danofloxacin mesylate
• Levofloxacin mesylate
• 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID