5,6-Dimethoxyindole Chemical Properties

Melting point:

154-157 °C (lit.)

Boiling point:

198°C 8mm

Density 

1.182±0.06 g/cm3(Predicted)

Flash point:

198°C/8mm

storage temp. 

Sealed in dry,Room Temperature

pka

16.93±0.30(Predicted)

form 

Powder

color 

Beige

Water Solubility 

Insoluble in water.

λmax

306nm(EtOH)(lit.)

BRN 

5683

InChIKey

QODBZRNBPUPLEZ-UHFFFAOYSA-N

CAS DataBase Reference

14430-23-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

22-24/25

WGK Germany 

3

F 

10

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5,6-Dimethoxyindole Usage And Synthesis

Chemical Properties

Beige powder

Uses

5,6-Dimethoxyindole is an indole derivative as analgesic antiinflammatory. It was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.

Application

5,6-Dimethoxyindole was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.
Reactant in synthesis of indolylhydroxyoxindoles via enantioselective Friedel-Crafts reaction
Reactant in synthesis of benzyl trimethoxyindoles
Reactant for synthesis of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors
Reactant for synthesis of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors
Reactant for preparation of tryptophanol derivatives via the Grignard reaction

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 5887, 1953 DOI: 10.1021/ja01119a030
Synthesis of 5,6-Dimethoxyindoles and 5,6-Dimethoxyoxindoles. A New Synthesis of Indoles DOI: 10.1021/ja01619a049

5,6-Dimethoxyindole(14430-23-0)Related Product Information

• oxypertine
• 5-Benzyloxy-6-methoxyindole
• 5,6-DIMETHOXY-2-PHENYLINDOLE
• 5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID
• 5,6-Dimethoxyindole
• Ethyl 5,6-dimethoxyindole-2-carboxylate, 98+%,ETHYL 5,6-DIMETHOXYINDOLE-2-CARBOXYLATE
• Alpertine
• 4,6-DIMETHOXYINDOLE
• 5-Methoxyindole
• 6-Methoxyindole
• 4-Methoxyindole
• 5,6-DIACETOXYINDOLE
• 5,6-DIBENZYLOXYINDOLE
• Duocarmycin A
• 6-BENZYLOXY-5-METHOXYINDOLE-2-CARBOXYLIC ACID
• METHYL-6,7-DIMETHOXY-4-ETHYL-BETA-CARBOLINE-3-CARBOXYLATE
• 5,6-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE
• 6,7-dimethoxyindole