2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine Chemical Properties

Boiling point:

421.7±55.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

pka

11.70±0.40(Predicted)

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine Usage And Synthesis

Uses

2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine is a mutagenic metablite of PhIP. PhIP is the most abundant mutagenic heterocyclic amine in cooked foods. Studies have shown the activation of 2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in the formation of PhIP adducts and 5-OH-PhIP.

Definition

ChEBI: N-hydroxy-PhIP is an imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. It has a role as a carcinogenic agent, a mutagen, a genotoxin, a human xenobiotic metabolite, a mouse metabolite, a rat metabolite and a neurotoxin. It is an imidazopyridine and a hydroxylamine. It is functionally related to a PhIP.

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine(124489-20-9)Related Product Information

• 1-Methyl-2-nitro-6-phenylimidazo[4,5-B]pyridine
• 1H-Imidazo[4,5-b]pyridin-2-amine(9CI)
• 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
• 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
• 1-Methyl-D3-2-nitro-6-phenylimidazo[4,5-B]pyridine
• 2-Amino-1,6-dimethylimidazo[4,5-b]pyridine
• 1H-Imidazo[4,5-b]pyridin-2-amine,1-methyl-