saintopin
saintopin Basic information
- Product Name:
- saintopin
- Synonyms:
-
- saintopin
- 1,3,8,10,11-Pentahydroxynaphthacene-5,12-dione
- CAS:
- 131190-63-1
- MF:
- C18H10O7
- MW:
- 0
- Mol File:
- 131190-63-1.mol
saintopin Usage And Synthesis
Uses
Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage[1][2].
Definition
ChEBI: A member of the class of tetracenequinones that is tetracene-5,12-dione in which the hydrogens at positions 1, 3, 8, 10, and 11 have been replaced by hydroxy groups. Isolated from Paecilomyces.
IC 50
Topoisomerase I; Topoisomerase II
References
[1] Yamashita Y, et al. Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces. J Antibiot (Tokyo). 1990 Oct;43(10):1344-6. DOI:10.7164/antibiotics.43.1344
[2] eteurtre F, et al. Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions. J Biol Chem. 1994 Nov 18;269(46):28702-7. PMID:7961822