8-hydroxyloxapine Chemical Properties

Melting point:

212-215°C

storage temp. 

Amber Vial, -20°C Freezer, Under Inert Atmosphere

solubility 

DMSO: soluble

form 

A solid

Stability:

Light Sensitive

8-hydroxyloxapine Usage And Synthesis

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α₁-adrenergic receptors (K_i values = 7, 7.7, 9.5, 12, and 31 nM for H₁, 5-HT_2A, 5-HT_2C, D₂, and α_1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [¹⁴C]5-HT uptake in vitro (IC₅₀ = 2 μM in human platelets).

Chemical Properties

Pale Yellow Solid

Uses

The inactive

8-hydroxyloxapine(61443-77-4)Related Product Information

• 8-METHOXY LOXAPINE
• 2-METHOXY-BENZAMIDINE HCL
• 1-(3-CHLOROBENZYL)PIPERAZINE
• 1-(2-METHOXYBENZYL) PIPERAZINE
• 4-(4-Chlorophenoxy)phenol
• 8-hydroxyloxapine
• CHEMBRDG-BB 4022460
• Dibenz-(b,f)-1,4-oxazephine
• Amoxapine
• 1-(2-PHENOXYPHENYL)METHANAMINE HYDROCHLORIDE
• 2-Hydroxy-benzamidine HCl
• loxapine